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雙氯西林鈉

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names：
Dicloxacillin Sodium hydrate
CAS號：
13412-64-1
MDL Number： MFCD00056865
MF(分子式)： C19H18Cl2N3NaO6S MW(分子量)： 510.32
EINECS:206-444-3 Reaxys Number:
Pubchem ID:23675786 Brand:BIOFOUNT

雙氯西林鈉(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)是雙氯西林的鈉鹽形式，雙氯西林鈉是一種廣譜，半合成的β-內(nèi)酰胺，具有抗細菌和β-內(nèi)酰胺酶的活性。雙氯西林鈉與位于細菌細胞壁內(nèi)膜上的青霉素結(jié)合蛋白（PBP）結(jié)合。雙氯西林鈉還能抑制肽聚糖（細菌細胞壁的關(guān)鍵成分）的交聯(lián)。這導致細菌細胞壁合成的抑制，并最終引起細胞裂解。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000227-50mg	50mg	98.94%	￥ 487.00	￥ 487.00		1-3days	- +	￥ 0.00

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中文別名	雙氯西林鈉(13412-64-1);全氟丁基磺酸鋰;雙氯青霉素鈉鹽水合物;雙氯西林鈉一水合物;BRL1702; BRL 1702；BRL-1702；P 1011；P-1011；P1011; 3-（2,6-二氯苯基）-5-甲基-4-異惡唑基青霉素;雙氯西林鈉水合物VETRAN;雙氯西林鈉EPD（CRM標準）;雙氯西林USP（CRM標準）;雙氯西林鈉（WHO（標準）） -Thia-1-azabicyclo3.2.0heptane-2-carbox；
英文別名	Dicloxacillin Sodium hydrate(13412-64-1);Dicloxacillin sodium salt monohydrate;BRL1702; BRL 1702; BRL-1702; P 1011; P-1011; P1011; 3-(2,6-DICHLOROPHENYL)-5-METHYL-4-ISOXAZOLYL PENICILLIN;DICLOXACILLIN SODIUM SALT HYDRATE VETRAN;DICLOXACILLIN SODIUM EPD(CRM STANDARD);DICLOXACILLIN SODIUM USP(CRM STANDARD);DICLOXACILLIN SODIUM WHO(CRM STANDARD);4-Thia-1-azabicyclo3.2.0heptane-2-carbox;
CAS號	13412-64-1
Inchi	InChI=1S/C19H17Cl2N3O5S.Na/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);/q;+1/p-1/t13-,14+,17-;/m1./s1
InchiKey	GXOMMGAFBINOJY-SLINCCQESA-M
分子式 Formula	C19H18Cl2N3NaO6S
分子量 Molecular Weight	510.32
溶解度Solubility	生物體外In Vitro:H2O : 25 mg/mL(48.99 mM;Need ultrasonic)
性狀	白色至類白色結(jié)晶性粉末,Power
儲藏條件 Storage conditions	-20°C 3 years，4°C 2 years ，In solvent -80°C 6 months ， -20°C 1 month

雙氯西林鈉(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)毒理性質(zhì)：

生物	測試類型	路線	劑量	影響	參考
man	TDLo	oral	71 mg/kg/5D-I (71 mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN; GASTROINTESTINAL: OTHER CHANGES; LIVER: JAUNDICE, CHOLESTATIC	Journal of Clinical Gastroenterology., 8(77), 1986
rat	LD50	oral	3579 mg/kg (3579 mg/kg)		Toxicology and Applied Pharmacology., 18(185), 1971 [PMID:5542824]
rat	LD50	intraperitoneal	630 mg/kg (630 mg/kg)		Arzneimittel-Forschung. Drug Research., 15(322), 1965 [PMID:5174841]
rat	LD50	intravenous	520 mg/kg (520 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
mouse	LD50	oral	4560 mg/kg (4560 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
mouse	LD50	intraperitoneal	1 gm/kg (1000 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
dog	LD50	oral	>3 gm/kg (3000 mg/kg)		Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
rabbit	LD50	oral	>5 gm/kg (5000 mg/kg)		Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
rabbit	LD50	intravenous	600 mg/kg (600 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
mouse	LD50	subcutaneous	1100 mg/kg (1100 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]
mouse	LD50	intravenous	875 mg/kg (875 mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA; GASTROINTESTINAL: OTHER CHANGES; LIVER: OTHER CHANGES	Japanese Journal of Antibiotics., 21(274), 1968 [PMID:5304362]

雙氯西林鈉(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags；雙氯西林鈉試劑,雙氯西林鈉雜質(zhì),雙氯西林鈉合成,雙氯西林鈉溶解度,雙氯西林鈉密度,雙氯西林鈉旋光度,雙氯西林鈉閃點,雙氯西林鈉熔點,雙氯西林鈉結(jié)構(gòu)式,雙氯西林鈉購買,

產(chǎn)品說明	雙氯西林鈉(13412-64-1,Dicloxacillin sodium salt monohydrate)是青霉素類的一種窄譜β-內(nèi)酰胺抗生素,用于治療易感的革蘭氏陽性細菌引起的感染
Introduction	雙氯西林鈉(13412-64-1,Dicloxacillin sodium salt monohydrate)is a narrowpectrum βactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gramositive bacteria,
Application1	雙氯西林鈉(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)active against betaactamaseroducing organisms such as Staphylococcus aureus.
Application2	雙氯西林鈉(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)對革蘭氏陽性細菌等產(chǎn)生的β-內(nèi)酰胺酶的生物（如金黃色葡萄球菌）具有活性。
Application3

雙氯西林鈉(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)藥理學：

1、雙氯西林鈉(β-內(nèi)酰胺化合物雙氯西林的一水合鈉鹽)形式可用作抗生素，尤其是針對革蘭氏陽性細菌的抗生素，在生物學研究中也具有重要意義。

2、Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) 是青霉素類的窄譜β內(nèi)酰胺抗生素, 可用于革蘭氏陽性菌感染的研究, 有效對抗β-內(nèi)酰胺酶產(chǎn)生的微生物如金黃色葡萄球菌。

3、雙氯西林鈉是雙氯西林的鈉鹽形式，它是一種廣譜，半合成的β-內(nèi)酰胺，具有抗細菌和β-內(nèi)酰胺酶的活性。雙氯西林鈉與位于細菌細胞壁內(nèi)膜上的青霉素結(jié)合蛋白（PBP）結(jié)合。它還能抑制肽聚糖（細菌細胞壁的關(guān)鍵成分）的交聯(lián)。這導致細菌細胞壁合成的抑制，并最終引起細胞裂解。

4、雙氯西林鈉是抗菌劑，雙氯西林鈉可以抑制細菌生長或繁殖的物質(zhì)。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

雙氯西林鈉(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)危害標識：

象形圖


信號	Danger
GHS危險說明	Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
	H315 (91.3%): Causes skin irritation [Warning Skin corrosion/irritation]
	H317 (10.87%): May cause an allergic skin reaction [Warning Sensitization, Skin]
	H319 (91.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
	H334 (97.83%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
	H335 (91.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
	Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范說明代碼	P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501
防范說明代碼	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Jusko WJ, et al. Enhanced renal excretion of dicloxacillin in patients with cystic fibrosis. Pediatrics. 1975 Dec;56(6):1038-44.

Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin

Second-derivative spectrophotometric assay of mixtures of dicloxacillin sodium and ampicillin sodium in pharmaceuticals PMID 3244108; Journal of pharmaceutical sciences 1988 Dec; 77(12):1042-6 Name ma

Bacteriology of acute otitis media in Japanese children PMID 6336890; American journal of diseases of children (1960) 1983 Feb; 137(2):152-4 Name matches: ampicillin sodium dicloxacillin sodium

Soft-tissue infections of ampicillin-resistant Haemophilus influenzae type b. The use of ampicillin and nafcillin in their treatment PMID 6972160; American journal of diseases of children (1960) 1981

雙氯西林鈉(13412-64-1,Dicloxacillin Sodium hydrate,Dicloxacillin sodium salt monohydrate)參考文獻：

1.Selective spectrophotometric determination of phenolic beta-lactam antibiotics.
Salem H1, Saleh GA. J Pharm Biomed Anal. 2002 Jun 15;28(6):1205-13.

Two simple and selective spectrophotometric methods were developed for the quantitative determination of cefoperazone sodium, cefadroxil monohydrate, cefprozil anhydrous and amoxicillin trihydrate in pure forms as well as in their pharmaceutical formulations. The methods are based on the selective oxidation of these drugs with either Ce (IV) or Fe (III) in acid medium to give an intense yellow coloured product (lambda(max)=397 nm). The reaction conditions were studied and optimized. Beer's plots were obeyed in a general concentration range of 5-30 microg ml(-1) with correlation coefficients not less than 0.9979 for the four drugs with the two reagents. The methods are successfully applied to the analysis of pharmaceutical formulations containing amoxicillin, either alone or in combination with potassium clavulanate, flucloxacillin or dicloxacillin. They were also applied to the analysis of the other three studied drugs in vials, capsules, tablets and suspensions with good recovery; percent ranged from 99.

2.Bacteriology of acute otitis media in Japanese children.
Fujita K, Iseki K, Yoshioka H, Sasaki T, Ando T, Nakamura M. Am J Dis Child. 1983 Feb;137(2):152-4.

Bacteriologic investigations were performed on 100 children with acute otitis media by culturing the fluid from a myringotomy site. Patients ranged in age from 7 months to 14 years, and 91 were younger than 6 years old. Bacterial isolates were yielded from cultures in 83 cases, and mixtures of two or three organisms were obtained from 15 patients. Among the total of 100 isolates, the most predominant organism was Streptococcus pneumoniae (28), followed by Hemophilus influenzae (26), Staphylococcus aureus (19), and Streptococcus pyogenes (six). Minimal inhibitory concentrations (MICs) of ampicillin sodium against S pneumoniae and H influenzae were 0.016 to 0.032 and 0.25 to 0.5 mg/L, respectively. None of the strains of H influenzae were resistant to ampicillin. The MICs of dicloxacillin sodium, cephalexin monohydrate, cefaclor, and erythromycin to H influenzae were 8 to 32, 8 to 16, 2 to 8, and 2 to 8 mg/L, respectively. The preferred drug for acute otitis media would be ampicillin in Japan, but we have to consider antistaphylococcal antibiotics for the patients who do not respond to 48 hours of treatment.

3.Sodium dicloxacillin monohydrate: an anti-staphylococcus antibiotic.
Keefe TJ, Christie GJ. Acta Chir Plast. 1973;15(1):904 passim.

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