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Somatrem

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names：
Somatrem
CAS號：
82030-87-3
MDL Number：
MF(分子式)： MW(分子量)：
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
DBK501898-500mg	500mg		￥ 0.00	￥ 0.00		Get quote	- +	￥ 0.00
DBK501898-100mg	100mg		￥ 0.00	￥ 0.00		Get quote	- +	￥ 0.00

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中文別名	Somatrem
英文別名	Somatrem
CAS號	82030-87-3
Inchi
InchiKey
分子式 Formula
分子量 Molecular Weight
溶解度Solubility
性狀	Liquid
儲藏條件 Storage conditions

Somatrem使用注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害。
3.取樣品的移液槍頭需及時更換，必要時為避免交叉污染盡可能選擇濾芯吸頭。
4.稱量藥品時選用稱量紙，并無風處取藥和稱量以免揚撒，試劑的容器使用前務必確保干凈，并消毒。
5.取藥品時盡量采用多個藥勺分別使用，使用后清洗干凈。
6.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染。
大規格定制：定制產品請將信息發送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

產品說明	Organic Acids
Introduction
Application1	Somatrem - as well as endogenous growth hormone - binds to dimeric growth hormone (GH) receptors located within the cell membranes of target tissue cells resulting in intracellular signal transduction and a host of pharmacodynamic effects2,Label. Some of these pharmacodynamic effects are primarily mediated by insulin like growth factor (IGF-1) produced in the liver and also locally (ie. skeletal growth, protein synthesis), while others are primarily a consequence of the direct effects of somatropin (ie. lipolysis)2,Label.Skeletal growth is accomplished at the epiphyseal plates at the ends of growing boneLabel. Growth and metabolism of epiphyseal plate cells are directly stimulated by GH and its mediator IGF-ILabel. Serum levels of IGF-I are low in children and adolescents who are growth hormone deficient, but increase during somatrem treatmentLabel. New bone is consequently formed at the epiphyses for paediatric patients in response to GH and IGF-I from somatrem treatmentLabel. This results in linear growth until these growth plates fuse at the end of pubertyLabel.Somatrem treatment also causes an increase in both the number and the size of skeletal muscle cellsLabel. Additionally, such therapy also influences the size of internal organs, including kidneys, and increases red cell massLabel.Linear skeletal bone growth is facilitated in part by GH-stimulated protein synthesisLabel. This is demonstrated by nitrogen retention as reflected by a decline in urinary nitrogen excretion and blood urea nitrogen (BUN) during somatrem therapyLabel. GH also acts as a modulator of carbohydrate metabolism which may improve a fasting hypoglycaemia feeling that some patients with inadequate GH secretion sometimes experienceLabel. Additionally, somatrem administration may decrease insulin sensitivity, resulting in increased serum fasting and postprandial insulin levels - usually more commonly in overweight or obese individuals, adults or childrenLabel. Moreover, mean fasting and postprandial glucose and hemoglobin A1C levels remained in the normal rangeLabel.Furthermore, in growth hormone deficient patients, the use of somatrem resulted in lipid mobilization, reduction in body fat stores, increased plasma fatty acids, and decreased plasma cholesterol levelsLabel. Serum levels of inorganic phosphorus may increase slightly in patients with inadequate secretion of endogenous GH, chronic kidney disease, or Turner syndrome during somatrem therapy due to metabolic activity associated with bone growth as well as increased tubular reabsorption of phosphate by the kidneyLabel. Serum calcium is not significantly altered in somatrem patientsLabel. Sodium retention and increases in serum alkaline phosphatase can occur to patients taking somatremLabel. As well, GH can stimulate the synthesis of chondroitin sulphate and collagen as well as the urinary excretion of hydroxyprolineLabel.TargetActionsOrganismAGrowth hormone receptoragonistHumansAInsulin-like growth factor 1 receptorNot AvailableHumans
Application2
Application3