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瑞芬新

NMR下載 COA and HPLC MSDS下載
names：
Revefenacin
CAS號：
864750-70-9
MDL Number：
MF(分子式)： C35H43N5O4 MW(分子量)： 597.76
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	瑞芬新
英文別名	Revefenacin
CAS號	864750-70-9
Inchi
InchiKey
分子式 Formula	C35H43N5O4
分子量 Molecular Weight	597.76
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions

瑞芬新使用注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害。
3.取樣品的移液槍頭需及時更換，必要時為避免交叉污染盡可能選擇濾芯吸頭。
4.稱量藥品時選用稱量紙，并無風處取藥和稱量以免揚撒，試劑的容器使用前務必確保干凈，并消毒。
5.取藥品時盡量采用多個藥勺分別使用，使用后清洗干凈。
6.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染。
大規格定制：定制產品請將信息發送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

產品說明	Organoheterocyclic compounds
Introduction
Application1	Revefenacin is an inhaled bronchodilator muscarinic antagonist with a long-acting bronchodilation activity.4It has been shown to present a high affinity and behaved as a competitive antagonist of the five muscarinic cholinergic receptors. Studies have indicated that revefenacin dissociates significantly slower from the muscarinic receptor M3 (hM3) when compared to the receptor M2 (hM2) which indicates a kinetic selectivity for this subtype. This competitive antagonism produces a suppressive action of the acetylcholine-evoked calcium mobilization and contractile responses in the airway tissue.5Lastly, due to the duration of the bronchodilation, revefenacin is considered a long-acting muscarinic antagonist which allows it to be dosed once daily.7This response is very important for the therapy of COPD as the main goal is the reduce the frequency and severity of exacerbations which are normally driven by the presence of elevated cholinergic bronchoconstrictor tone mediated by muscarinic receptors on parasympathetic ganglia and airway smooth muscle.6Hence, the activity of revefenacin produces a potent and long-lasting protection against the bronchoconstrictor response to acetylcholine or methacholine.5TargetActionsOrganismAMuscarinic acetylcholine receptorantagonistHumans
Application2
Application3