購物車 
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BB-3497
- names：
Hexanamide, N-((1S)-1-((dimethylamino)carbonyl)-2,2-dimethylpropyl)-2-((formylhydroxyamino)methyl)-, (2R)-
- CAS號(hào)：
235784-88-0
MDL Number： - MF(分子式)： C16H31N3O4 MW(分子量)： 329.441
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫存描述 | 數(shù)量 | 總計(jì) (￥) |
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| 中文別名 | BB-3497 |
| 英文別名 | BB-3497; BB3497; BB 3497 |
| CAS號(hào) | 235784-88-0 |
| Inchi | InChI=1S/C16H31N3O4/c1-7-8-9-12(10-19(23)11-20)14(21)17-13(16(2,3)4)15(22)18(5)6/h11-13,23H,7-10H2,1-6H3,(H,17,21)/t12-,13-/m1/s1 |
| InchiKey | AVDLWYHBABSSHC-CHWSQXEVSA-N |
| 分子式 Formula | C16H31N3O4 |
| 分子量 Molecular Weight | 329.441 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲(chǔ)藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說明 | BB-3497(CAS:235784-88-0):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | BB-3497 is a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Kumari T, Issar U, Kakkar R. Docking modes of BB-3497 into the PDF active site--a comparison of the pure MM and QM/MM based docking strategies. Curr Comput Aided Drug Des. 2014;10(4):315-26. PubMed PMID: 25994638. |
| [2]Sharma A, Khuller GK, Kanwar AJ, Sharma S. Therapeutic potential of peptide deformylase inhibitors against experimental tuberculosis. J Infect. 2010 Jun;60(6):498-501. doi: 10.1016/j.jinf.2010.03.009. Epub 2010 Mar 25. PubMed PMID: 20346970. |
| [3] Sharma A, Sharma S, Khuller GK, Kanwar AJ. In vitro and ex vivo activity of peptide deformylase inhibitors against Mycobacterium tuberculosis H37Rv. Int J Antimicrob Agents. 2009 Sep;34(3):226-30. doi: 10.1016/j.ijantimicag.2009.04.005. Epub 2009 Jun 7. PubMed PMID: 19505802. |
| [4] Guay DR. Drug forecast - the peptide deformylase inhibitors as antibacterial agents. Ther Clin Risk Manag. 2007 Aug;3(4):513-25. PubMed PMID: 18472972; PubMed Central PMCID: PMC2374925. |
| [5] Huang J, Van Aller GS, Taylor AN, Kerrigan JJ, Liu WS, Trulli JM, Lai Z, Holmes D, Aubart KM, Brown JR, Zalacain M. Phylogenomic and biochemical characterization of three Legionella pneumophila polypeptide deformylases. J Bacteriol. 2006 Jul;188(14):5249-57. PubMed PMID: 16816197; PubMed Central PMCID: PMC1539947. |
6: Van Aller GS, Nandigama R, Petit CM, DeWolf WE Jr, Quinn CJ, Aubart KM, Zalacain M, Christensen SB, Copeland RA, Lai Z. Mechanism of time-dependent inhibition of polypeptide deformylase by actinonin. Biochemistry. 2005 Jan 11;44(1):253-60. PubMed PMID: 15628866.7: Cynamon MH, Alvirez-Freites E, Yeo AE. BB-3497, a peptide deformylase inhibitor, is active against Mycobacterium tuberculosis. J Antimicrob Chemother. 2004 Feb;53(2):403-5. Epub 2003 Dec 19. PubMed PMID: 14688038.8: East SP, Beckett RP, Brookings DC, Clements JM, Doel S, Keavey K, Pain G, Smith HK, Thomas W, Thompson AJ, Todd RS, Whittaker M. Peptide deformylase inhibitors with activity against respiratory tract pathogens. Bioorg Med Chem Lett. 2004 Jan 5;14(1):59-62. PubMed PMID: 14684298.9: Davies SJ, Ayscough AP, Beckett RP, Clements JM, Doel S, Pratt LM, Spavold ZM, Thomas SW, Whittaker M. Structure--activity relationships of the peptide deformylase inhibitor BB-3497: modification of the P2' and P3' side chains. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2715-8. PubMed PMID: 12873500.10: Davies SJ, Ayscough AP, Beckett RP, Bragg RA, Clements JM, Doel S, Grew C, Launchbury SB, Perkins GM, Pratt LM, Smith HK, Spavold ZM, Thomas SW, Todd RS, Whittaker M. Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2709-13. PubMed PMID: 12873499.1
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