購物車 
-
BB-83698
- names：
Cyclopentanepropanamide, N-((1S)-1-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)carbonyl)-2,2-dimethylpropyl)-alpha-((formylhydroxyamino)methyl)-, (alphaR)-
- CAS號：
325795-25-3
MDL Number： - MF(分子式)： C28H42N4O6 MW(分子量)： 530.666
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|
| 中文別名 | BB-83698 |
| 英文別名 | BB-83698; BB 83698; BB83698 |
| CAS號 | 325795-25-3 |
| Inchi | InChI=1S/C28H42N4O6/c1-28(2,3)25(29-26(34)22(17-32(36)18-33)14-20-6-4-5-7-20)27(35)31-12-10-30(11-13-31)16-21-8-9-23-24(15-21)38-19-37-23/h8-9,15,18,20,22,25,36H,4-7,10-14,16-17,19H2,1-3H3,(H,29,34)/t22-,25-/m1/s1 |
| InchiKey | IBEANEPZNLVRRY-RCZVLFRGSA-N |
| 分子式 Formula | C28H42N4O6 |
| 分子量 Molecular Weight | 530.666 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產品說明 | BB-83698(CAS:325795-25-3):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。 |
| Introduction | BB-83698 is a peptide deformylase inhibitor and potent antimicrobial with excellent activity against streptococci and Moraxella catarrhalis strains. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Sangshetti JN, Khan FA, Shinde DB. Peptide deformylase: a new target in antibacterial, antimalarial and anticancer drug discovery. Curr Med Chem. 2015;22(2):214-36. Review. PubMed PMID: 25174923. |
| [2]Guay DR. Drug forecast - the peptide deformylase inhibitors as antibacterial agents. Ther Clin Risk Manag. 2007 Aug;3(4):513-25. PubMed PMID: 18472972; PubMed Central PMCID: PMC2374925. |
| [3] Wang Q, Wang J, Cai Z, Xu W. Prediction of the binding modes between BB-83698 and peptide deformylase from Bacillus stearothermophilus by docking and molecular dynamics simulation. Biophys Chem. 2008 May;134(3):178-84. doi: 10.1016/j.bpc.2008.02.003. Epub 2008 Feb 16. PubMed PMID: 18321635. |
| [4] Khurdayan V, Bozzo J, Sorbera L. Chronicles in drug discovery. Drug News Perspect. 2005 Jun;18(5):332-6. PubMed PMID: 16193105. |
| [5] Chen D, Yuan Z. Therapeutic potential of peptide deformylase inhibitors. Expert Opin Investig Drugs. 2005 Sep;14(9):1107-16. Review. PubMed PMID: 16144495. |
6: Jain R, Chen D, White RJ, Patel DV, Yuan Z. Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents. Curr Med Chem. 2005;12(14):1607-21. Review. PubMed PMID: 16022661.7: Johnson KW, Lofland D, Moser HE. PDF inhibitors: an emerging class of antibacterial drugs. Curr Drug Targets Infect Disord. 2005 Mar;5(1):39-52. Review. PubMed PMID: 15777197.8: Ramanathan-Girish S, McColm J, Clements JM, Taupin P, Barrowcliffe S, Hevizi J, Safrin S, Moore C, Patou G, Moser H, Gadd A, Hoch U, Jiang V, Lofland D, Johnson KW. Pharmacokinetics in animals and humans of a first-in-class peptide deformylase inhibitor. Antimicrob Agents Chemother. 2004 Dec;48(12):4835-42. PubMed PMID: 15561864; PubMed Central PMCID: PMC529202.9: Lofland D, Difuntorum S, Waller A, Clements JM, Weaver MK, Karlowsky JA, Johnson K. In vitro antibacterial activity of the peptide deformylase inhibitor BB-83698. J Antimicrob Chemother. 2004 Apr;53(4):664-8. Epub 2004 Feb 18. PubMed PMID: 14973152.10: Azoulay-Dupuis E, Mohler J, Bédos JP. Efficacy of BB-83698, a novel peptide deformylase inhibitor, in a mouse model of pneumococcal pneumonia. Antimicrob Agents Chemother. 2004 Jan;48(1):80-5. PubMed PMID: 14693522; PubMed Central PMCID: PMC310171.1
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