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Debrisoquin hydrobromide

NMR下載 COA and HPLC MSDS下載
names：
2(1H)-Isoquinolinecarboxamidine, 3,4-dihydro-, hydrobromide
CAS號(hào)：
1131-66-4
MDL Number：
MF(分子式)： C10H14BrN3 MW(分子量)： 256.147
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Debrisoquin hydrobromide
英文別名	Debrisoquin hydrobromide; Ro 5-3307; Debrisoquin HCl.
CAS號(hào)	1131-66-4
Inchi	InChI=1S/C10H13N3.BrH/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;/h1-4H,5-7H2,(H3,11,12);1H
InchiKey	VTSAHPTZGHRJSO-UHFFFAOYSA-N
分子式 Formula	C10H14BrN3
分子量 Molecular Weight	256.147
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Debrisoquin hydrobromide(CAS:1131-66-4):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Debrisoquin hydrobromide, the hydrobromide salt form of dextromethorphan, a synthetic, methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.
Application1
Application2
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警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
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[1]Irshaid YM, al-Hadidi HF, Latif A, Awwadi F, al-Zoubi M, Rawashdeh NM. Dextromethorphan metabolism in Jordanians: dissociation of dextromethorphan O-demethylation from debrisoquine 4-hydroxylation. Eur J Drug Metab Pharmacokinet. 1996 Oct-Dec;21(4):301-7. PubMed PMID: 9074894.

[2]Hou ZY, Chen CP, Yang WC, Lai MD, Buchert ET, Chung HM, Pickle LW, Woosley RL. Determination of dextromethorphan metabolic phenotype by salivary analysis with a reference to genotype in Chinese patients receiving renal hemodialysis. Clin Pharmacol Ther. 1996 Apr;59(4):411-7. PubMed PMID: 8612385.

[3] Hou ZY, Pickle LW, Meyer PS, Woosley RL. Salivary analysis for determination of dextromethorphan metabolic phenotype. Clin Pharmacol Ther. 1991 Apr;49(4):410-9. PubMed PMID: 2015730.

[4] Schmid B, Bircher J, Preisig R, Küpfer A. Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation. Clin Pharmacol Ther. 1985 Dec;38(6):618-24. PubMed PMID: 4064464.

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