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Dianhydromannitol

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names：
(3R,4S)-hexa-1,5-diene-2,3,4,5-tetraol
CAS號：
19895-66-0
MDL Number：
MF(分子式)： C6H10O4 MW(分子量)： 146.14
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Dianhydromannitol
英文別名	Dianhydromannitol; DADM; NSC-133129; UNII-DPHVJPYRKV; 1256-Dianhydro-D-mannitol;
CAS號	19895-66-0
Inchi	InChI=1S/C6H10O4/c1-3(7)5(9)6(10)4(2)8/h5-10H,1-2H2/t5-,6+
InchiKey	PICUSLXKOFIWAJ-OLQVQODUSA-N
分子式 Formula	C6H10O4
分子量 Molecular Weight	146.14
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Dianhydromannitol(CAS:19895-66-0):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Dianhydromannitol, Dihyro- and tetrahydrofuran building blocks from 1,43,6-dianhydromannitol. 1,2-Anhydro-6-bromo-6-deoxygalactitol (BrEpG) and its D-mannitol analogue (BrEpM) intermediary metabolites in the conversion of dibromodulcitol (DBD) and dibromomannitol (DBM) into dianhydrogalactitol (DAG) and dianhydromannitol (DAM) have been prepared. The three types of derivative of each hexitol have been compared in their toxicities towards mice, tumour inhibitory activities against the Walker carcinosarcoma and haematological effects in rats. The bromoepoxides showed intermediate potency in all tests. The galactitol derivatives were always more potent than their mannitol counterparts. The mannitol derivatives were selectively myelosuppressive, being twice as toxic towards granulocytes as towards lymphocytes. The lymphotoxic activity of DBM, in particular, relative to its other toxic effects was particularly mild. These differences have been ascribed principally to the more rapid reactivity of DAG compared with DAM towards target nucleophiles, modulated by the influence of the bromine substituent on the transport properties of the dibromo- and bromoepoxy-derivatives.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]GREGORY H, WIGGINS LF. Anhydrides of polyhydric alcohols; some alkenyl ethersof 1 : 4-3 : 6-dianhydromannitol and 1 ; 4-3 : 6-dianhydrosorbitol. J Chem Soc.1947 Oct:1405-7. PubMed PMID: 20272142.

[2]MONTGOMERY R, WIGGINS LF. Anhydrides of polyhydric alcohols;1:4-

[3]6-dianhydromannitol and 1:4-

3:6-dianhydro sorbitol from sucrose. J ChemSoc. 1947 Apr:433-6. PubMed PMID: 20249751.

[5] Horváth IP, Somfai-Relle S, Hegedüs L, Jarman M. Toxicity, antitumour andhaematological effects of 1,2-anhydro-6-bromogalactitol and d-mannitol: acomparison with the related dibromo- and dianhydro-derivatives. Eur J Cancer ClinOncol. 1982 Jun;18(6):573-7. PubMed PMID: 6811281.

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SDS 1.0 英文

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