購物車 
-
FR 113680
- names：
L-Phenylalaninamide, N-acetyl-L-threonyl-1-formyl-D-tryptophyl-N-methyl-N-(phenylmethyl)-
- CAS號：
126088-92-4
MDL Number： - MF(分子式)： C35H39N5O6 MW(分子量)： 625.71
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|
| 中文別名 | FR 113680 |
| 英文別名 | FR 113680; FR113680; FR-113680; Ac-Thr-trp(cho)-phe-N-mebzl. |
| CAS號 | 126088-92-4 |
| Inchi | InChI=1S/C35H39N5O6/c1-23(42)32(37-24(2)43)35(46)40(33(44)29(36)19-27-21-39(22-41)30-17-11-10-16-28(27)30)34(45)31(18-25-12-6-4-7-13-25)38(3)20-26-14-8-5-9-15-26/h4-17,21-23,29,31-32,42H,18-20,36H2,1-3H3,(H,37,43)/t23-,29-,31+,32+/m1/s1 |
| InchiKey | GUMFSDXELXANKA-KGLGFYCJSA-N |
| 分子式 Formula | C35H39N5O6 |
| 分子量 Molecular Weight | 625.71 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產品說明 | FR 113680(CAS:126088-92-4):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。 |
| Introduction | FR 113680 is a novel tripeptide substance P antagonist with NK1 receptor selectivity. The inhibitory effect of FR 113680 on SP-induced guinea-pig ileum contraction is competitive and the pA2 value is 7.53. It suggest that FR 113680 interacts selectively with the NK1 neurokinin receptor. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Caliendo G, Greco G, Grieco P, Perissutti E, Santagada V, Calignano A, Mancuso F, Novellino E. Synthesis and in vitro activities of highly potent and selective tripeptide antagonists of the neurokinin NK-1 receptor. Farmaco. 1995 Nov;50(11):755-9. PubMed PMID: 8593172. |
| [2]Caliendo G, Calignano A, Grieco P, Mancuso F, Perissutti E, Santini A, Santagada V. Synthesis and biological activity of tripeptide FR113680 analogues containing unconventional amino acids. Biopolymers. 1995 Oct;36(4):409-14. PubMed PMID: 7578938. |
| [3] Hagiwara D, Miyake H, Igari N, Murano K, Morimoto H, Murai M, Fujii T, Matsuo M. Design of a novel dipeptide substance P antagonist FK888. Regul Pept. 1993 Jul 2;46(1-2):332-4. PubMed PMID: 7692528. |
| [4] Morimoto H, Yamashita M, Matsuda A, Miyake H, Fujii T. Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation. Eur J Pharmacol. 1992 Nov 24;224(1):1-5. PubMed PMID: 1280594. |
| [5] Hagiwara D, Miyake H, Morimoto H, Murai M, Fujii T, Matsuo M. Studies on neurokinin antagonists. 2. Design and structure-activity relationships of novel tripeptide substance P antagonists, N alpha-[N alpha-(N alpha-acetyl-L-threonyl)-N1-formyl-D-tryptophyl]-N- methyl-N-(phenylmethyl)-L-phenylalaninamide and its related compounds. J Med Chem. 1992 Aug 21;35(17):3184-91. PubMed PMID: 1380560. |
6: Murai M, Morimoto H, Maeda Y, Fujii T. Effects of the tripeptide substance P antagonist, FR113680, on airway constriction and airway edema induced by neurokinins in guinea-pigs. Eur J Pharmacol. 1992 Jun 24;217(1):23-9. PubMed PMID: 1383004.7: Morimoto H, Murai M, Maeda Y, Hagiwara D, Miyake H, Matsuo M, Fujii T. FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity. Br J Pharmacol. 1992 May;106(1):123-6. PubMed PMID: 1380378; PubMed Central PMCID: PMC1907453.8: Patacchini R, Santicioli P, Astolfi M, Rovero P, Viti G, Maggi CA. Activity of peptide and non-peptide antagonists at peripheral NK1 receptors. Eur J Pharmacol. 1992 Apr 29;215(1):93-8. PubMed PMID: 1381319.
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