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Levuglandin E2

NMR下載 COA and HPLC MSDS下載
names：
(5Z,8R,9R,10E,12S)-8-acetyl-9-formyl-12-hydroxyheptadeca-5,10-dienoic acid
CAS號：
91712-41-3
MDL Number：
MF(分子式)： C20H32O5 MW(分子量)： 352.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Levuglandin E2
英文別名	Levuglandin E2;
CAS號	91712-41-3
Inchi	InChI=1S/C20H32O5/c1-3-4-7-10-18(23)14-13-17(15-21)19(16(2)22)11-8-5-6-9-12-20(24)25/h5,8,13-15,17-19,23H,3-4,6-7,9-12H2,1-2H3,(H,24,25)/b8-5-,14-13+/t17-,18-,19-/m0/s1
InchiKey	WJWAORNTZNRHBP-QNUMDXCLSA-N
分子式 Formula	C20H32O5
分子量 Molecular Weight	352.47
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Levuglandin E2(CAS:91712-41-3):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Levuglandin E2 is a secoprostanoid from prostaglandin endoperoxide; gamma-ketoaldehyde cpd; related to prostaglandin E2.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Iyer RS, Ghosh S, Salomon RG. Levuglandin E2 crosslinks proteins. Prostaglandins. 1989 Apr;37(4):471-80. PubMed PMID: 2762557.

[2]Murthi KK, Salomon RG, Sternlicht H. Levuglandin E2 inhibits mitosis and microtubule assembly. Prostaglandins. 1990 Jun;39(6):611-22. PubMed PMID: 2115185.

[3] Hoppe G, Subbanagounder G, O'Neil J, Salomon RG, Hoff HF. Macrophage recognition of LDL modified by levuglandin E2, an oxidation product of arachidonic acid. Biochim Biophys Acta. 1997 Jan 7;1344(1):1-5. PubMed PMID: 9022751.

[4] Salomon RG, Jirousek MR, Ghosh S, Sharma RB. Prostaglandin endoperoxides 21. Covalent binding of levuglandin E2 with proteins. Prostaglandins. 1987 Nov;34(5):643-56. PubMed PMID: 3481092.

[5] Jirousek MR, Murthi KK, Salomon RG. Electrophilic levuglandin E2-protein adducts bind glycine: a model for protein crosslinking. Prostaglandins. 1990 Aug;40(2):187-203. PubMed PMID: 2217833.

6: Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA. Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. Biochemistry. 2014 Apr 22;53(15):2436-41. doi: 10.1021/bi401673b. Epub 2014 Apr 11. PubMed PMID: 24684440; PubMed Central PMCID: PMC4004227.7: DiFranco E, Subbanagounder G, Kim S, Murthi K, Taneda S, Monnier VM, Salomon RG. Formation and stability of pyrrole adducts in the reaction of levuglandin E2 with proteins. Chem Res Toxicol. 1995 Jan-Feb;8(1):61-7. PubMed PMID: 7703368.8: Murthi KK, Friedman LR, Oleinick NL, Salomon RG. Formation of DNA-protein cross-links in mammalian cells by levuglandin E2. Biochemistry. 1993 Apr 20;32(15):4090-7. PubMed PMID: 8471616.9: Salomon RG, Sha W, Brame C, Kaur K, Subbanagounder G, O'Neil J, Hoff HF, Roberts LJ 2nd. Protein adducts of iso[4]levuglandin E2, a product of the isoprostane pathway, in oxidized low density lipoprotein. J Biol Chem. 1999 Jul 16;274(29):20271-80. PubMed PMID: 10400646.10: Salomon RG, Subbanagounder G, O'Neil J, Kaur K, Smith MA, Hoff HF, Perry G, Monnier VM. Levuglandin E2-protein adducts in human plasma and vasculature. Chem Res Toxicol. 1997 May;10(5):536-45. PubMed PMID: 9168251.1

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