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Sotrastaurin acetate

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names：
1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(2-(4-methyl-1-piperazinyl)-4-quinazolinyl)-, acetate
CAS號：
908351-31-5
MDL Number：
MF(分子式)： C27H26N6O4 MW(分子量)： 498.54
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(2-(4-methyl-1-piperazinyl)-4-quinazolinyl)-, acetate
英文別名	Sotrastaurin acetate;
CAS號	908351-31-5
Inchi	InChI=1S/C25H22N6O2.C2H4O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18;1-2(3)4/h2-9,14,26H,10-13H2,1H3,(H,29,32,33);1H3,(H,3,4)
InchiKey	RVEUYBMXVVDLFO-UHFFFAOYSA-N
分子式 Formula	C27H26N6O4
分子量 Molecular Weight	498.54
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Sotrastaurin acetate(CAS:908351-31-5):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Sotrastaurin acetate is a pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護(hù)
備注

[1]Wallner FK, Hultquist Hopkins M, Woodworth N, Lindvall Bark T, Olofsson P, Tilevik A. Correlation and cluster analysis of immunomodulatory drugs based on cytokine profiles. Pharmacol Res. 2018 Feb;128:244-25[1]doi: 10.1016/j.phrs.2017.10.012. Epub 2017 Oct 25. PubMed PMID: 29079427.

[2]Zheng J, Kong C, Yang X, Cui X, Lin X, Zhang Z. Protein kinase C-α (PKCα) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder. BMC Cancer. 2017 Jun 19;17(1):432. doi: 10.1186/s12885-017-3401-7. PubMed PMID: 28629334; PubMed Central PMCID: PMC5477139.

[3] El-Gamal D, Williams K, LaFollette TD, Cannon M, Blachly JS, Zhong Y, Woyach JA, Williams E, Awan FT, Jones J, Andritsos L, Maddocks K, Wu CH, Chen CS, Lehman A, Zhang X, Lapalombella R, Byrd JC. PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL. Blood. 2014 Aug 28;124(9):1481-91. doi: 10.1182/blood-2014-05-574830. Epub 2014 Jul 7. PubMed PMID: 25001469; PubMed Central PMCID: PMC4148770.

[4] Capsoni F, Ongari AM, Reali E, Bosè F, Altomare GF. The protein kinase C inhibitor AEB071 (sotrastaurin) modulates migration and superoxide anion production by human neutrophils in vitro. Int J Immunopathol Pharmacol. 2012 Jul-Sep;25(3):617-26. PubMed PMID: 23058012.

[5] Jakab A, Winter S, Guy B, Raccuglia M, Picard F, Kovarik JM, Chudasama J, Guttikar S, Singhal P, Kretz O. Validation of a liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of Sotrastaurin and its metabolite N-desmethyl-sotrastaurin in human blood. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 15;897:10-6. doi: 10.1016/j.jchromb.2012.03.039. Epub 2012 Apr 2. PubMed PMID: 22541169.

6: Matz M, Weber U, Mashreghi MF, Lorkowski C, Ladhoff J, Kramer S, Neumayer HH, Budde K. Effects of the new immunosuppressive agent AEB071 on human immune cells. Nephrol Dial Transplant. 2010 Jul;25(7):2159-67. doi: 10.1093/ndt/gfp775. Epub 2010 Jan 25. PubMed PMID: 20100729.7: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008 Apr;30(3):231-51. PubMed PMID: 18597009.

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