購(gòu)物車(chē) 
-
Withanolide B
- names：
(5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,722,26-diepoxyergosta-2,24-diene-1,26-dione
- CAS號(hào)：
56973-41-2
MDL Number： - MF(分子式)： C28H38O5 MW(分子量)： 454.607
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫(kù)存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|
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| 中文別名 | (5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,722,26-diepoxyergosta-2,24-diene-1,26-dione |
| 英文別名 | Withanolide B |
| CAS號(hào) | 56973-41-2 |
| Inchi | InChI=1S/C28H38O5/c1-14-13-20(32-25(30)15(14)2)16(3)17-8-9-18-22-19(10-12-26(17,18)4)27(5)21(29)7-6-11-28(27,31)24-23(22)33-24/h6-7,16-20,22-24,31H,8-13H2,1-5H3/t16-,17+,18-,19-,20+,22-,23+,24+,26+,27-,28-/m0/s1 |
| InchiKey | ZTEVDTFJUUJBLP-HGSBMKTESA-N |
| 分子式 Formula | C28H38O5 |
| 分子量 Molecular Weight | 454.607 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲(chǔ)藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說(shuō)明 | Withanolide B(CAS:56973-41-2):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does not increase glucose uptake in L6 myotubes. In in silico docking studies, withanolide B was identified as a neuronal nitric oxide synthase (nNOS) inhibitor that also inhibited inducible NOS (iNOS) and endothelial NOS and as a ligand for the PARP1 catalytic domain. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Ben Bakrim W, El Bouzidi L, Nuzillard JM, Cretton S, Saraux N, Monteillier A, Christen P, Cuendet M, Bekkouche K. Bioactive metabolites from the leaves of Withania adpressa. Pharm Biol. 2018 Dec;56(1):505-510. doi: 10.1080/13880209.2018.149978[1]PubMed PMID: 30451050; PubMed Central PMCID: PMC6249549. |
| [2]Dubey S, Kallubai M, Sarkar A, Subramanyam R. Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin. PLoS One. 2018 Nov 7;13(11):e0200053. doi: 10.1371/journal.pone.0200053. eCollection 2018. PubMed PMID: 30403672; PubMed Central PMCID: PMC6221254. |
| [3] Hussain H, Csuk R, Green IR, Ur Rehman N, Abbas G, Hussain W. Journey Describing the Cytotoxic Potential of Withanolides: A Patent Review. Recent Pat Anticancer Drug Discov. 2018;13(4):411-421. doi: 10.2174/1574892813666180808154928. Review. PubMed PMID: 30091418. |
| [4] Mishra A, Singh SP, Mahfooz S, Bhattacharya A, Mishra N, Shirke PA, Nautiyal CS. Bacterial endophytes modulates the withanolide biosynthetic pathway and physiological performance in Withania somnifera under biotic stress. Microbiol Res. 2018 Jul - Aug;212-21 |
| [5]17-28. doi: 10.1016/j.micres.2018.04.006. Epub 2018 Apr 22. PubMed PMID: 29853165. |
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