購物車 
-
草苔蟲素 1
- names：
Bryostatin 1
- CAS號：
83314-01-6
MDL Number： MFCD00893832 - MF(分子式)： C47H68O17 MW(分子量)： C47H68O17
- EINECS: Reaxys Number:
- Pubchem ID:5280757 Brand:BIOFOUNT
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|---|---|---|---|---|---|---|---|
| DBK502017-500mg | 500mg | ￥ 0.00 | ￥ 0.00 | Get quote | ￥ 0.00 | |||
| DBK502017-100mg | 100mg | ￥ 0.00 | ￥ 0.00 | Get quote | ￥ 0.00 |
| 中文別名 | 草苔蟲素 -1；草苔蟲素雜質；草苔蟲素 A; |
| 英文別名 | Bryostatin 1； UNII-37O2X55Y9E； 83314-01-6； NSC 339555； CHEMBL449158； Bryostatin-1； CHEBI:88353； 7O2X55Y9E； BRYOSTATIN； BRN 4349157；[(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate;EH9455000 |
| CAS號 | 83314-01-6 |
| Inchi | InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1 |
| InchiKey | MJQUEDHRCUIRLF-TVIXENOKSA-N |
| 分子式 Formula | C47H68O17 |
| 分子量 Molecular Weight | C47H68O17 |
| 溶解度Solubility | |
| 性狀 | white;solid; power |
| 儲藏條件 Storage conditions | Store at -4℃； -20℃存儲更長時間（2-3年） |
| 產品說明 | Bryostatin 1是從具有抗腫瘤活性的苔蘚蟲（Bugula neritina）分離的大環內酯。 Bryostatin 1結合并抑制細胞信號轉導酶蛋白激酶C，從而抑制腫瘤細胞增殖，促進腫瘤細胞分化和誘導腫瘤細胞凋亡，該試劑可以與其他化學治療劑協同作用。 |
| Introduction | Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells |
| Application1 | Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects |
| Application2 | Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon |
| Application3 | The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line |
Bryostatin 1是從具有抗腫瘤活性的苔蘚蟲（Bugula neritina）分離的大環內酯。 Bryostatin 1結合并抑制細胞信號轉導酶蛋白激酶C，從而抑制腫瘤細胞增殖，促進腫瘤細胞分化和誘導腫瘤細胞凋亡。 該試劑可以與其他化學治療劑協同作用。
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
| 警示圖 | |
| 危險性 | |
| 危險性警示 | Mouse(iv): LD50: 0.075 mg/kg;Rat(iv): LD50: 0.068 mg/kg |
| 安全聲明 | H303+H313+H333 |
| 安全防護 | P264+P280+P305+P351+P338+P337+P313 |
| 備注 |
| New Approaches to the Total Synthesis of the Bryostatin Antitumor Macrolides Chem. Asian J. 2010,10.1002/asia.200900634 |
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