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Cridanimod sodium

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names：
Sodium 2-(9-oxoacridin-10(9H)-yl)acetate
CAS號：
58880-43-6
MDL Number：
MF(分子式)： C15H10NNaO3 MW(分子量)： 275.23
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Cridanimod sodium
英文別名	Cridanimod sodium; Cridanimod Na; Sodium Cridanimod; XBIO101; XBIO-101; XBIO 101; Cycloferon; Cyclopheron;
CAS號	58880-43-6
Inchi	InChI=1S/C15H11NO3.Na/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16;/h1-8H,9H2,(H,17,18);/q;+1/p-1
InchiKey	FQMLTEAEJZVTAJ-UHFFFAOYSA-M
分子式 Formula	C15H10NNaO3
分子量 Molecular Weight	275.23
溶解度Solubility
性狀	A crystalline solid
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Cridanimod sodium(CAS:58880-43-6 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Cridanimod, also known as XBIO-101, is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells.
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[1]Cavlar, T., Deimling, T., Ablasser, A., et al. Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32(10), 1440-1450 (2013).2. Taylor, J.L., Schoenherr, C.K., and Grossberg, S.E. High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamsters. Antimicrob. Agents Chemother. 18(1), 20-26 (1980).3. Kramer, M.J., Cleeland, R., and Grunberg, E. Antiviral activity of 10-carboxymethyl-9-acridanone. Antimicrob. Agents Chemother. 9(2), 233-238 (1976).4. Surkov, K.G., Tsyrlina, E.V., Konstantinova, M.M., et al. Neovir, an interferon inductor, modifies expression of steroid hormone receptors in hormone-dependent tissues and restores sensitivity to tamoxifen in patients with inoperable breast cancer. Vopr. Onkol. 42(6), 28-32 (1996).