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Isomazole
- names：
2-(2-Methoxy-4-methylsulfinylphenyl)-3H-imidazo[4,5-c]pyridine
- CAS號：
86315-52-8
MDL Number： - MF(分子式)： C14H13N3O2S MW(分子量)： 287.337
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫存描述 | 數(shù)量 | 總計(jì) (￥) |
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| 中文別名 | Isomazole |
| 英文別名 | Isomazole |
| CAS號 | 86315-52-8 |
| Inchi | InChI=1S/C14H13N3O2S/c1-19-13-7-9(20(2)18)3-4-10(13)14-16-11-5-6-15-8-12(11)17-14/h3-8H,1-2H3,(H,16,17) |
| InchiKey | JQUKCPUPFALELS-UHFFFAOYSA-N |
| 分子式 Formula | C14H13N3O2S |
| 分子量 Molecular Weight | 287.337 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說明 | Isomazole(CAS:86315-52-8 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Isomazole is a potent inotropic agent, inhibiting both PDE3 and PDE4. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Borasio PG, Cervellati F, Pavan B, Pareschi MC. "Low" concentrations of sodium fluoride inhibit neurotransmitter release from the guinea-pig superior cervical ganglion. Neurosci Lett. 2004 Jul 1;364(2):86-9. PubMed PMID: 15196683. |
| [2]Utkan T, Yildirim MK, Yildirim S, Sarioglu Y. Effects of the specific phosphodiesterase inhibitors on alloxan-induced diabetic rabbit cavernous tissue in vitro. Int J Impot Res. 2001 Feb;13(1):24-30. PubMed PMID: 11313837. |
| [3] Dorigo P, Floreani M, Santostasi G, Maragno I, Danieli-Betto D, Germinario E, Magno SM, Primofiore G, Marini AM, Da Settimo F. Pharmacological characterization of a new Ca(2+) sensitizer. J Pharmacol Exp Ther. 2000 Dec;295(3):994-1004. PubMed PMID: 11082434. |
| [4] Andreani A, Leoni A, Morigi R, Bossa R, Chiericozzi M, Galatulas I. In vivo cardiotonic activity of aryl- and pyridyl-substituted fused imidazoles. Arzneimittelforschung. 1998 Mar;48(3):232-5. PubMed PMID: 9553678. |
| [5] Van der Ent M, Remme WJ, Bartels GL, De Leeuw PW, Van Hoogenhuyze DC, Kruijssen DA. Contrasting preload-dependent hemodynamic and neurohumoral effects of isomazole, a partial phosphodiesterase inhibitor and calcium sensitizer. J Card Fail. 1997 Dec;3(4):277-86. PubMed PMID: 9547442. |
6: De Mey C, Erb K, Schroeter V, Belz GG. Differentiation of inodilatory responses by non-invasive measures of cardiovascular performance in healthy man. Int J Clin Pharmacol Ther. 1996 Dec;34(12):525-32. PubMed PMID: 8996846.7: Hata K, Goto Y, Futaki S, Takasago T, Saeki A, Nishioka T, Suga H. Effects of milrinone and sulmazole on left ventricular mechanoenergetics in canine hearts. J Card Fail. 1996 Sep;2(3):203-13. PubMed PMID: 8891859.8: Bossa R, Bissoli M, Chiericozzi M, Cozzi R, Galatulas I, Salvatore G. Reduction of adriamycin cardiotoxicity by enoximone. Anticancer Res. 1996 Jan-Feb;16(1):141-3. PubMed PMID: 8615599.9: De Mey C. Method specificity of the auscultatory estimates of the inodilatory reduction of diastolic blood pressure based on Korotkoff IV and V criteria. Br J Clin Pharmacol. 1995 May;39(5):485-90. PubMed PMID: 7669483; PubMed Central PMCID: PMC1365054.10: Kelso EJ, McDermott BJ, Silke B. Actions of the novel vasodilator, flosequinan, in isolated ventricular cardiomyocytes. J Cardiovasc Pharmacol. 1995 Mar;25(3):376-86. PubMed PMID: 7769801.1
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