購物車 
-
ATFB, SE
- names：
ATFB, SE;非熒光雙功能光反應交聯(lián)探針
- CAS號：
126695-58-7
MDL Number： MFCD00467437 - MF(分子式)： C11H4F4N4O4 MW(分子量)： 332.17
- EINECS: Reaxys Number:
- Pubchem ID:2762579 Brand:BIOFOUNT
ATFB, SE(4-N3Pfp-NHS ester,126695-58-7)是一種非熒光雙功能光反應交聯(lián)探針，也是一種不可降解 (non-cleavable) 的 ADC linker，N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸用于抗體偶聯(lián)藥物 (ADCs) 的合成。
| 貨品編碼 | 規(guī)格 | 純度 | 價格 (￥) | 現(xiàn)價(￥) | 特價(￥) | 庫存描述 | 數(shù)量 | 總計 (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM001009-5mg | 5mg | >97% | ￥ 0.00 | ￥ 0.00 | Backorder | ￥ 0.00 | ||
| YZM001009-1mg | 1mg | >97% | ￥ 1200.00 | ￥ 1200.00 | 1-3天 | ￥ 0.00 |
| 中文別名 | N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸(126695-58-7);4-疊氮基-2,3,5,6-四氟苯甲酸N-琥珀酰亞胺酯;N-琥珀酰亞胺4-疊氮-2,3,5,6-四氟苯甲酸;4-AZIDChemicalbookO-2,3,5,6-TETRAFLUOROBENZOICACID2,5-DIOXO-PYRROLIDIN-1-YLESTER;4-疊氮基2,3,5,6-四氟苯甲酸，N-琥珀酰亞胺酯;ATFB SE; |
| 英文別名 | 4-N3Pfp-NHS ester(126695-58-7);Succinimidylester(ATFB,SE);4-Azido-2,3,5,6-tetrafluorobenzoicAcid,N-SuccinimidylEster,ATFBSE;2,5-dioxopyrrolidin-1-yl4-azido-2,3,5,6-tetrafluorobenzoate;4-N3Pfp-NHSester;4-N3PFP-NHSESTERChemicalbook;ATFB,SE[4-Azido-2,3,5,6-tetrafluorobenzoicacid,succiniMidylester];N-Succinimidyl4-Azido-2,3,5,6-tetrafluorobenzoate>;4-azido-2，3，5，6-tetrafluorobenzoicacid2，5-dioxo-pyrrolidin-1-ylester; |
| CAS號 | 126695-58-7 |
| Inchi | InChI=1S/C7HF4N3O2/c8-2-1(7(15)16)3(9)5(11)6(4(2)10)13-14-12/h(H,15,16) |
| InchiKey | IOJFHZXQSLNAQJ-UHFFFAOYSA-N |
| 分子式 Formula | C11H4F4N4O4 |
| 分子量 Molecular Weight | 332.17 |
| 溶解度Solubility | |
| 性狀 | 灰白色至淺黃色固體 |
| 儲藏條件 Storage conditions | 惰性氣氛下的-20°C冷凍琥珀色小瓶，對光和濕氣敏感。存放在冰箱中 |
ATFB, SE 實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tags:126695-58-7試劑,126695-58-7雜質(zhì),126695-58-7合成,126695-58-7中間體,126695-58-7密度,126695-58-7溶解度,126695-58-7旋光度,126695-58-7閃點,126695-58-7熔點,126695-58-7購買,
| 產(chǎn)品說明 | N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)是一種有效的不可降解的ADC連接橋，用于抗體藥物結(jié)合物 (ADCs) 的合成 |
| Introduction | N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)is a noncleavableADC linkerused in the synthesis of antibodyrug conjugates (ADCs). |
| Application1 | |
| Application2 | |
| Application3 |
N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)藥理學：
N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)是一種不可降解 (non-cleavable) 的 ADC linker，N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸用于抗體偶聯(lián)藥物 (ADCs) 的合成。
N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)是一種不可降解 (non-cleavable) 的 ADC linker，N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸用于抗體偶聯(lián)藥物 (ADCs) 的合成。
| 警示圖 | |
| 危險性 | warning |
| 危險性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害 |
| 安全防護 | P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理 |
| 備注 | 實驗過程中防止吸入、食入，做好安全防護 |
4-N3Pfp-NHS ester 126695-58-7)危害標識：
| 象形圖 |  |
| 信號 | Warning |
| GHS危險說明 | The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
| H228 (100%): Flammable solid [Danger Flammable solids] | |
| H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] | |
| H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] | |
| 防范說明代碼 | P210, P240, P241, P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, and P370+P378 |
| (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Pyrene fluorescence quenching by aromatic azides Kinetics and Catalysis 2006 |
| Tri- and Tetravalent Photoactivable Cross-Linking Agents Synthesis 2012 10.1055/s-0031-1290444 |
| UV crosslinking of PVDF-based polymers for gate dielectric insulators of organic thin film transistors 2018-08-17，CN-110838546-A |
| Uv crosslinking of pvdf-based polymers for gate dielectric insulators of organic thin-film transistors 2018-08-17，WO-2020036761-A1 |
| Array of polymeric hydrogel nanostructures and their uses 2018-08-06，WO-2020033227-A2 |
N -琥珀酰亞胺4 -疊氮- 2,3,5,6-四氟苯甲酸(4-N3Pfp-NHS ester,126695-58-7)參考文獻：
1、Pyrene fluorescence quenching by aromatic azides
S. V. Kamyshan, S. V. Litvinchuk, V. V. Korolev, S. I. Eremenko, Yu. P. Tsentalovich & N. P. Gritsan
Abstract Pyrene fluorescence quenching by phenylazide derivatives with donor and acceptor substituents has been studied by fluorescence spectroscopy and flash photolysis. The rate constants of quenching (k q) in acetonitrile ((0.2–1.2) × 1010 l mol−1 s−1) are found to be close to a diffusion limit; the rate constants were somewhat higher for perfluoro-substituted arylazides. It is found that k q does not depend on solvent polarity; the formation of the pyrene cation in the course of pyrene fluorescence quenching by tolylazide was not detected. Pyrene fluorescence quenching occurred by an energy-transfer mechanism; this is supported by the coincidence of the quantum yields of the direct and sensitized photodecomposition of tolylazide. As estimated, energy transfer in rigid media occurs at characteristic distances of about 10 Å.
2、Tri- and Tetravalent Photoactivable Cross-Linking Agents
Alexandre Welle, François Billard, Jacqueline Marchand-Brynaert*
Abstract A modular synthesis of photoactivable cross-linking agents is described, using an aromatic core, di- or triethyleneglycol spacers and photoaffinity labeling synthons that feature either perfluorophenyl azide or aryl(trifluoromethyl)diazirine motifs. Symmetrical and nonsymmetrical trivalent structures were obtained from phloroglucinol and dopamine, respectively. Symmetrical tetravalent structures resulted from the coupling of two dopamine derivatives with oxalyl chloride.
1、Pyrene fluorescence quenching by aromatic azides
S. V. Kamyshan, S. V. Litvinchuk, V. V. Korolev, S. I. Eremenko, Yu. P. Tsentalovich & N. P. Gritsan
Abstract Pyrene fluorescence quenching by phenylazide derivatives with donor and acceptor substituents has been studied by fluorescence spectroscopy and flash photolysis. The rate constants of quenching (k q) in acetonitrile ((0.2–1.2) × 1010 l mol−1 s−1) are found to be close to a diffusion limit; the rate constants were somewhat higher for perfluoro-substituted arylazides. It is found that k q does not depend on solvent polarity; the formation of the pyrene cation in the course of pyrene fluorescence quenching by tolylazide was not detected. Pyrene fluorescence quenching occurred by an energy-transfer mechanism; this is supported by the coincidence of the quantum yields of the direct and sensitized photodecomposition of tolylazide. As estimated, energy transfer in rigid media occurs at characteristic distances of about 10 Å.
2、Tri- and Tetravalent Photoactivable Cross-Linking Agents
Alexandre Welle, François Billard, Jacqueline Marchand-Brynaert*
Abstract A modular synthesis of photoactivable cross-linking agents is described, using an aromatic core, di- or triethyleneglycol spacers and photoaffinity labeling synthons that feature either perfluorophenyl azide or aryl(trifluoromethyl)diazirine motifs. Symmetrical and nonsymmetrical trivalent structures were obtained from phloroglucinol and dopamine, respectively. Symmetrical tetravalent structures resulted from the coupling of two dopamine derivatives with oxalyl chloride.
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