購物車 
-
Anguizole
- names：
Anguizole
- CAS號：
442666-98-0
MDL Number： MFCD03308216 - MF(分子式)： C17H11ClF2N4O2S MW(分子量)： 408.81
- EINECS: Reaxys Number:
- Pubchem ID:1046082 Brand:BIOFOUNT
Anguizole(cas:442666-98-0)是HCV復制的小分子抑制劑，能改變NS4B的亞細胞分布。
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM000582-10mg | 10mg | 99.33% | ￥ 1694.00 | ￥ 1694.00 | 2-3天 | ￥ 0.00 | ||
| YZM000582-5mg | 5mg | 99.33% | ￥ 978.90 | ￥ 978.90 | 2-3天 | ￥ 0.00 |
| 中文別名 | Anguizole(cas:442666-98-0) |
| 英文別名 | Anguizole(cas:442666-98-0),7-[Chlor(difluor)methyl]-5-(2-furyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidin-2-carboxamid |
| CAS號 | 442666-98-0 |
| Inchi | InChI=1S/C17H11ClF2N4O2S/c18-17(19,20)14-7-11(13-4-1-5-26-13)22-15-8-12(23-24(14)15)16(25)21-9-10-3-2-6-27-10/h1-8H,9H2,(H,21,25) |
| InchiKey | GBNREAYNZPJROB-UHFFFAOYSA-N |
| 分子式 Formula | C17H11ClF2N4O2S |
| 分子量 Molecular Weight | 408.81 |
| 溶解度Solubility | 生物體外In Vitro:DMSO溶解度50 mg/mL(122.31 mM;Need ultrasonic)H2O< 0.1 mg/mL(insoluble) |
| 性狀 | 固體粉末,Power |
| 儲藏條件 Storage conditions | -20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月 |
Anguizole(CAS:442666-98-0)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:Anguizole蒸汽壓,Anguizole合成,Anguizole標準,Anguizole應用,Anguizole合成,Anguizole沸點,Anguizole閃點,Anguizole用途,Anguizole溶解度,Anguizole價格,Anguizole作用,Anguizole結構式,Anguizole用處
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:Anguizole蒸汽壓,Anguizole合成,Anguizole標準,Anguizole應用,Anguizole合成,Anguizole沸點,Anguizole閃點,Anguizole用途,Anguizole溶解度,Anguizole價格,Anguizole作用,Anguizole結構式,Anguizole用處
| 產品說明 | Anguizole(442666-98-0)是HCV復制的小分子抑制劑，能改變NS4B的亞細胞分布。 |
| Introduction | Anguizole(442666-98-0) is a small molecule inhibitor of HCV replication and alters NS4B's subcellular distribution.IC50 Value: |
| Application1 | |
| Application2 | |
| Application3 |
| 警示圖 | |
| 危險性 | warning |
| 危險性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害 |
| 安全防護 | P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理 |
| 備注 | 實驗過程中防止吸入、食入，做好安全防護 |
| 2014-03-13 Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives Journal of medicinal chemistry |
| 2013-12-01 A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B's dimerization/multimerization as well as its interaction with NS5A Virus genes |
| 2010-07-01 A small molecule inhibits HCV replication and alters NS4B's subcellular distribution Antiviral research |
| A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B’s dimerization/multimerization as well as its interaction with NS5A Virus Genes 2013 |
| A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B's dimerization/multimerization as well as its interaction with NS5A PMID 23868571; Virus genes 2013 Dec; 47(3) |
A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B's dimerization/multimerization as well as its interaction with NS5A/PMID 23868571; Virus genes 2013 Dec; 47(3):395-407/Name matches: chronic hepatitis c anguizole
Abstract：Chronic hepatitis C virus (HCV) infection is responsible for severe liver diseases including liver cirrhosis and hepatocellular carcinoma. An HCV non-structural protein 4B (NS4B) plays an essential role in viral RNA genome replication by building multi-vesicular structures around endoplasmic reticulum membranes. Especially, the second amphipathic helix of NS4B (NS4B-AH2) was shown to be essential for this process. By screening compounds against a membrane-aggregating activity of NS4B-AH2, several anti-HCV replication small molecules targeting NS4B-AH2 were discovered. However, little is known about detailed molecular mechanism of action for these NS4B-AH2 inhibitors. In this report, we provide evidences that NS4B-AH2 is required for NS4B's dimerization/multimerization, its proper subcellular localization, as well as its interaction with NS5A. More importantly, one of NS4B-AH2 inhibitors called "anguizole" was found to be able to disrupt all of these NS4B-AH2-mediated biological functions of NS4B. This newly elucidated mechanism of action will enable us not only to better understand a central role of NS4B-AH2 in HCV life cycle but also to develop a more safe and effective new class of NS4B-AH2 inhibitors of HCV replication in the future.
Abstract：Chronic hepatitis C virus (HCV) infection is responsible for severe liver diseases including liver cirrhosis and hepatocellular carcinoma. An HCV non-structural protein 4B (NS4B) plays an essential role in viral RNA genome replication by building multi-vesicular structures around endoplasmic reticulum membranes. Especially, the second amphipathic helix of NS4B (NS4B-AH2) was shown to be essential for this process. By screening compounds against a membrane-aggregating activity of NS4B-AH2, several anti-HCV replication small molecules targeting NS4B-AH2 were discovered. However, little is known about detailed molecular mechanism of action for these NS4B-AH2 inhibitors. In this report, we provide evidences that NS4B-AH2 is required for NS4B's dimerization/multimerization, its proper subcellular localization, as well as its interaction with NS5A. More importantly, one of NS4B-AH2 inhibitors called "anguizole" was found to be able to disrupt all of these NS4B-AH2-mediated biological functions of NS4B. This newly elucidated mechanism of action will enable us not only to better understand a central role of NS4B-AH2 in HCV life cycle but also to develop a more safe and effective new class of NS4B-AH2 inhibitors of HCV replication in the future.
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