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福斯他沙韋

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names：
Fostemsavir Tris
CAS號：
864953-39-9
MDL Number： MFCD23098797
MF(分子式)： C29H37N8O11P MW(分子量)： 704.62
EINECS: Reaxys Number:
Pubchem ID:46892186 Brand:BIOFOUNT

福斯他沙韋(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)是HIV-1附著抑制劑,可用于治療HIV-1感染。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000692-5mg	5mg		￥ 2156.00	￥ 2156.00		Backorder	- +	￥ 0.00
YZM000692-2mg	2mg	>97%	￥ 1170.00	￥ 1170.00		2-3天	- +	￥ 0.00

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中文別名	福斯他沙韋(864953-39-9);福斯沙韋氨丁三醇;
英文別名	Fostemsavir Tris(864953-39-9);Fostemsavir tromethamine; BMS-663068 Tris; BMS 663068 Tris; BMS663068 Tris Publication citing BOC Sciences Products;
CAS號	864953-39-9
Inchi	InChI=1S/C25H26N7O8P.C4H11NO3/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17;5-4(1-6,2-7)3-8/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38);6-8H,1-3,5H2
InchiKey	RRGJSMBMTOKHTE-UHFFFAOYSA-N
分子式 Formula	C29H37N8O11P
分子量 Molecular Weight	704.62
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	請根據產品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description.

福斯他沙韋(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	福斯他沙韋(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)是一種新型附著抑制劑,靶向HIV-1gp120,可防止其與CD4 + T細胞結合.
Introduction	福斯他沙韋(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)is the phosphonooxymethyl prodrug of BMS26529.
Application1	Fostemsavir Tris (BMS63068 (Tris)) is a novel attachment inhibitor that targetsHIVgp120 and prevents its binding to CD4+T cells.
Application2
Application3

福斯他沙韋(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)藥理學：

BMS-663068 tris是開發中的HIV-1附著抑制劑，可用于治療HIV-1感染。IC50值：目標：HIVBMS-663068是BMS-626529的前藥，它與病毒包膜糖蛋白gp120結合并干擾病毒與細胞CD4受體的附著。在有或沒有利托那韋的情況下，連續8天使用BMS-663068會導致血漿HIV-1 RNA水平大幅下降，并且通常具有良好的耐受性。BMS-663068作為抗逆轉錄病毒療法聯合治療的一部分，需要進行長期的臨床試驗。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

福斯他沙韋(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)危害標識：

象形圖

信號	Warning
GHS危險說明	Aggregated GHS information provided by 5 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
	H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
	H361 (60%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
	H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
	Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范說明代碼	P201, P202, P260, P261, P272, P280, P281, P302+P352, P308+P313, P314, P321, P333+P313, P363, P405, and P501
	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507

福斯他沙韋(Fostemsavir Tris,864953-39-9,BMS-663068 Tris)參考文獻：

1、In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068
Beata Nowicka-Sans 1, Yi-Fei Gong, Brian McAuliffe, Ira Dicker, Hsu-Tso Ho, Nannan Zhou, Betsy Eggers, Pin-Fang Lin, Neelanjana Ray, Megan Wind-Rotolo, Li Zhu, Antara Majumdar, David Stock, Max Lataillade, George J Hanna, John D Matiskella, Yasutsugu Ueda, Tao Wang, John F Kadow, Nicholas A Meanwell, Mark Krystal

Abstract BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. In order to better understand the anti-HIV-1 spectrum of BMS-626529 against HIV-1, in vitro activities against a wide variety of laboratory strains and clinical isolates were determined. BMS-626529 had half-maximal effective concentration (EC(50)) values of <10 nM against the vast majority of viral isolates; however, susceptibility varied by >6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses. The in vitro antiviral activity of BMS-626529 was generally not associated with either tropism or subtype, with few exceptions. Measurement of the binding affinity of BMS-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life. Finally, in two-drug combination studies, BMS-626529 demonstrated additive or synergistic interactions with antiretroviral drugs of different mechanistic classes. These results suggest that BMS-626529 should be active against the majority of HIV-1 viruses and support the continued clinical development of the compound.

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