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卡波啶

NMR下載 COA and HPLC MSDS下載
names：
Carbodine
CAS號：
71184-20-8
MDL Number：
MF(分子式)： C10H15N3O4 MW(分子量)： 241.24
EINECS: Reaxys Number:
Pubchem ID:130540 Brand:BIOFOUNT

卡波啶(71184-20-8,Carbodine,碳環胞苷)是一種廣譜抗病毒藥物，對DNA病毒，（+）RNA病毒，（-）RNA病毒，paramyxo，rhabdo和（+/-）RNA病毒具有活性，可以將UTP轉換Carbodine（Carbocyclic cytidine）在體外具有顯著的抗流感病毒A0 / PR-8 / 34和A2 / Aichi / 2/68活性。為CTP的CTP合成酶。

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YZM000740-100mg	100mg	>97%	￥ 0.00	￥ 0.00		2-3天	- +	￥ 0.00

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中文別名	卡波啶(71184-20-8);卡賓丁;卡賓定;(R-（1alpha，2alpha，3beta，4alpha））-異構體;碳環胞苷;DTXSID40991504;3-（2-羥基-4-亞氨基嘧啶-1（4H）-基）-5-（羥甲基）環戊烷-1,2-二醇;2（1H）-嘧啶酮，4-氨基-1-（2,3-二羥基-4-（羥甲基）環戊基）-，（1R-（1alpha，2beta，3beta，4alpha））-;
英文別名	Carbodine(71184-20-8);carbocyclic cytidine;carbodine, (R-(1alpha,2alpha,3beta,4alpha))-isomer;Carbocyclic cytidine;DTXSID40991504;3-(2-Hydroxy-4-iminopyrimidin-1(4H)-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol;2(1H)-Pyrimidinone, 4-amino-1-(2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-, (1R-(1alpha,2beta,3beta,4alpha))-;
CAS號	71184-20-8
Inchi	InChI=1S/C14H22O4S/c1-13(2,3)9-14(4,5)10-6-7-11(15)12(8-10)19(16,17)18/h6-8,15H,9H2,1-5H3,(H,16,17,18)
InchiKey	LSAIQLOHXQZJCH-UHFFFAOYSA-N
分子式 Formula	C10H15N3O4
分子量 Molecular Weight	241.24
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	請根據產品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description.

卡波啶(71184-20-8,Carbodine,碳環胞苷)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	卡波啶(71184-20-8,Carbodine,碳環胞苷)具有活性的廣譜抗病毒劑,卡波啶具有顯著的抗病毒活性
Introduction	卡波啶(71184-20-8,Carbodine)is a broad-spectrum antiviral agent active against DNA viruses(+)RNA viruses(-)RNA virusesparamyxo,rhabdo and(+/-)RNA viruses,targets CTP synthetase that converts UTP to CTP.
Application1
Application2
Application3

卡波啶(71184-20-8,Carbodine,碳環胞苷)藥理學：

卡波啶（碳環胞苷）是一種廣譜抗病毒劑，對DNA病毒，（+）RNA病毒，（-）RNA病毒，副粘病毒，彈狀病毒和（+/-）RNA病毒具有活性，靶向將UTP轉換為CTP的CTP合成酶。Carbodine（碳環胞苷）在體外對A0 / PR-8 / 34和A2 / Aichi / 2/68型流感病毒具有顯著的抗病毒活性。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

De Clercq E, et al. Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine. Biochem Pharmacol. 1990 Jan 15;39(2):319-25.

Shannon WM, et al. Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses.

卡波啶(71184-20-8,Carbodine,碳環胞苷)參考文獻：

1、CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase
M Huang 1, Y Wang, M Collins, L M Graves

Abstract Cyclopentenyl cytosine (CPEC) is a carbocyclic cytidine analog inhibitor of CTP synthetase and experimental drug for combination chemotherapy. CPEC treatment (50 nM) depleted intracellular CTP and induced a specific S-phase arrest and erythroid differentiation of human erythroleukemia K562 cells. The equilibrative nucleoside transporters (ENT1, 2) facilitated uptake of CPEC into K562 cells as evidenced by both NBMPR and dipyridamole inhibition of CPEC-mediated CTP depletion and erythroid differentiation. Incubation with the pyridinylimidazole p38 MAPK inhibitors, SB203580 or SB220025, suppressed both the CPEC-induced cell cycle arrest and differentiation of K562 cells. SB203580 also prevented the cell cycle arrest and erythroid differentiation of K562 cells induced by Leflunomide (LEF), a non-nucleoside inhibitor of the de novo pyrimidine pathway, without affecting LEF-induced depletion of pyrimidine pools. Finally, selective knockdown of p38 MAPK by using Smart Pooltrade mark siRNA to p38 MAPK significantly decreased the CPEC-induced differentiation of K562 cells. These results suggest that endogenous activity of p38 MAP kinases may be required for committing K562 cells to cell cycle arrest and erythroid differentiation under conditions of CTP depletion.

2、Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine
E De Clercq 1, R Bernaerts, Y F Shealy, J A Montgomery

Abstract Carbocyclic cytidine (C-Cyd) is a broad-spectrum antiviral agent active against DNA viruses [pox (vaccinia)], (+)RNA viruses [toga (Sindbis, Semliki forest), corona], (-)RNA viruses [orthomyxo (influenza), paramyxo (parainfluenza, measles), rhabdo (vesicular stomatitis)] and (+/-)RNA viruses (reo). The target enzyme of C-Cyd is supposed to be CTP synthetase that converts UTP to CTP. In keeping with this assumption are the observations that (i) C-Cyd effects a dose-dependent inhibition of RNA synthesis in both virus-infected and uninfected cells, and (ii) exogenous addition of either Urd or Cyd reverses both the antiviral and cytocidal activity of C-Cyd, whereas addition of dThd or dCyd fails to do so. The selectivity of C-Cyd against Sindbis, vesicular stomatitis and reo virus is markedly increased when C-Cyd is combined with Cyd (10 micrograms/mL). This combination may therefore be worth pursuing as a chemotherapeutic modality for the treatment of virus infections.

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