DSM265

NMR下載 COA and HPLC MSDS下載
names：
DSM265
CAS號：
1282041-94-4
MDL Number： NA
MF(分子式)： C14H12F7N5S MW(分子量)： 415.33
EINECS:826-984-9 Reaxys Number:1282041-94-4
Pubchem ID:NA Brand:BIOFOUNT

DSM265(DSM265,1282041-94-4) has been used in trials studying the prevention and treatment of Malaria.

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000764-5mg	5mg	99.59%	￥ 3341.00	￥ 3341.00		2-3天	- +	￥ 0.00
YZM000764-1mg	1mg	99.59%	￥ 1072.50	￥ 1072.50		2-3天	- +	￥ 0.00

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中文別名	DSM265(DSM265,1282041-94-4)
英文別名	DSM265(DSM265,1282041-94-4)
CAS號	1282041-94-4
Inchi	InChI=1S/C14H12F7N5S/c1-8-7-11(26-13(22-8)24-12(25-26)14(2,15)16)23-9-3-5-10(6-4-9)27(17,18,19,20)21/h3-7,23H,1-2H3
InchiKey	OIZSVTOIBNSVOS-UHFFFAOYSA-N
分子式 Formula	C14H12F7N5S
分子量 Molecular Weight	415.33
溶解度Solubility
性狀	固體粉末,Power
儲藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

DSM265(DSM265,1282041-94-4)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	DSM265(DSM265,1282041-94-4)是一種有效的長效的惡性瘧原蟲二氫乳清酸脫氫酶PfDHODH的抑制劑.
Introduction	DSM265(DSM265,1282041-94-4) is an effective long-acting inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase PfDHODH.
Application1
Application2
Application3

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria /PMID: 29909069

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study The Lancet. Infectious diseases/PMID: 28363636

DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection The Lancet. Infectious diseases/PMID: 28363637

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria Science translational medicine/PMID: 26180101

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria Science translational medicine/PMID: 21696174

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

Abstract:Background: DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against blood and liver stages of Plasmodium falciparum. This study aimed to assess the efficacy of DSM265 in patients with P falciparum or Plasmodium vivax malaria infection.