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Chitinase-IN-1

NMR下載 COA and HPLC MSDS下載
names：
Chitinase-IN-1
CAS號：
1579991-61-9
MDL Number：
MF(分子式)： C18H16N4O2S MW(分子量)： 352.41
EINECS: Reaxys Number:
Pubchem ID:86223063 Brand:BIOFOUNT

Chitinase-IN-1(1579991-61-9)是昆蟲幾丁質酶和N-乙酰基己糖胺酶的抑制劑和殺蟲劑；Chitinase-IN-1在50 uM和20uM化合物濃度時對幾丁質酶和N-乙酰基己糖胺酶的抑制率分別為75％和67％。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000821-5mg	5mg	99%	￥ 3540.00	￥ 3540.00		2-3天	- +	￥ 0.00
YZM000821-2mg	2mg	99%	￥ 2274.00	￥ 2274.00		2-3天	- +	￥ 0.00

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中文別名	Chitinase-IN-1(1579991-61-9)
英文別名	Chitinase-IN-1,1579991-61-9
CAS號	1579991-61-9
Inchi	InChI=1S/C18H16N4O2S/c1-11-20-21-15(25-11)10-19-8-9-22-17(23)13-6-2-4-12-5-3-7-14(16(12)13)18(22)24/h2-7,19H,8-10H2,1H3
InchiKey	YHPDOCZSFWEMOD-UHFFFAOYSA-N
分子式 Formula	C18H16N4O2S
分子量 Molecular Weight	352.41
溶解度Solubility	生物體外In Vitro:DMSO溶解度50 mg/mL(141.88 mM;Need ultrasonic)
性狀	固體粉末,Power
儲藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 /溶液中:-80°C 6 months月 -20°C 1 month月

Chitinase-IN-1(1579991-61-9)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染

Chitinase-IN-1(1579991-61-9) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	Chitinase-IN-1(1579991-61-9)是昆蟲幾丁質酶和N-乙酰基己糖胺酶的抑制劑和殺蟲劑
Introduction	Chitinase-IN-1(1579991-61-9) is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide
Application1
Application2
Application3

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs(Scientific Reports,2014)

Abstract:Selective inhibition of function-specific β-GlcNAcase has great potential in terms of drug design and biological research. The symmetrical bis-naphthalimide M-31850 was previously obtained by screening for specificity against human glycoconjugate-lytic β-GlcNAcase. Using protein-ligand co-crystallization and molecular docking, we designed an unsymmetrical dyad of naphthalimide and thiadiazole, Q2, that changes naphthalimide specificity from against a human glycoconjugate-lytic β-GlcNAcase to against insect and bacterial chitinolytic β-GlcNAcases. The crystallographic and in silico studies reveal that the naphthalimide ring can be utilized to bind different parts of these enzyme homologs, providing a new starting point to design specific inhibitors. Moreover, Q2-induced closure of the substrate binding pocket is the structural basis for its 13-fold increment in inhibitory potency. Q2 is the first non-carbohydrate inhibitor against chitinolytic β-GlcNAcases. This study provides a useful example of structure-based rationally designed inhibitors as potential pharmaceuticals or pesticides.

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