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帕硝唑

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names：
Panidazole
CAS號：
13752-33-5
MDL Number： MFCD00866604
MF(分子式)： C11H12N4O2 MW(分子量)： 232.24
EINECS:237-334-3 Reaxys Number:
Pubchem ID:72080 Brand:BIOFOUNT

帕硝唑(13752-33-5,Panidazole)是一種5-硝基咪唑衍生物，是一種殺蟲劑，對體外溶血性變形桿菌和陰道毛滴蟲顯示出有效的體外活性。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000822-5mg	5mg	99.6%	￥ 2025.00	￥ 2025.00		2-3天	- +	￥ 0.00
YZM000822-1mg	1mg	99.6%	￥ 975.00	￥ 975.00		2-3天	- +	￥ 0.00

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中文別名	帕硝唑(13752-33-5,Panidazole);甲硝咪乙啶
英文別名	Panidazole(13752-33-5)
CAS號	13752-33-5
Inchi	InChI=1S/C11H12N4O2/c1-9-13-8-11(15(16)17)14(9)7-4-10-2-5-12-6-3-10/h2-3,5-6,8H,4,7H2,1H3
InchiKey	ARYPMCPJIWUCIP-UHFFFAOYSA-N
分子式 Formula	C11H12N4O2
分子量 Molecular Weight	232.24
溶解度Solubility	生物體外In Vitro:DMSO溶解度≥ 125 mg/mL(538.24 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性狀	白色至灰白色固體粉末
儲藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 /溶液中:-80°C 6 months月 -20°C 1 month月

帕硝唑(13752-33-5,Panidazole)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染

Panidazole(13752-33-5) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Panidazole(13752-33-5),Panidazole試劑,Panidazole抑制劑,Panidazole的作用,Panidazole的純度,Panidazole的合成,Panidazole的生產,Panidazole的含量,Panidazole的使用,Panidazole的廠家,Panidazole的外觀,Panidazole的MSDS,Panidazole的注意事項

產品說明	帕硝唑(13752-33-5,Panidazole)是一種5-硝基咪唑衍生物，是一種殺蟲劑，對體外溶血性變形桿菌和陰道毛滴蟲顯示出有效的體外活性。
Introduction	Panidazole(13752-33-5,帕硝唑), a 5-nitroimidazole derivative, is an amoebicide that showed potent in vitro activity against Entamoeba histolytica and Trichomonas vaginalis.
Application1
Application2
Application3

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

1-(2-(γ-Pyridyl)ethyl)-2-methyl-5-nitro-imidazole (Panidazole), A new amoebicide(Experientia,1970)

Cross-resistance of trichomonads to 5-nitroimidazole-derivatives(Experientia,1976)

The Pharmacology and Toxicology of 5-Nitroimidazoles(Nitroimidazoles,1982)

Resistance to 5-Nitroimidazoles in Pathogenic Microorganisms(Nitroimidazoles,1982)

Blastocystis hominis: neutral red supravital staining and its application to in vitro drug sensitivity testing(Parasitology Research,2000)

Botero D, et al. Treatment of intestinal amoebiasis and vaginal trichomoniasis with panidazole and its comparison with metronidazole. Trans R Soc Trop Med Hyg. 1977;71(6):508-11.
Abstract:A dose range study in 18 patients suffering from intestinal amoebiasis and treated with doses of panidazole between 1.0 and 2.0 g per day for six days revealed that the best therapeutic results were obtained with the higher dose. This dose was then compared with metronidazole, at the same dose, in a clinical trial in 100 patients with intestinal amoebiasis. Cure rates were 68% and 80% for the two drugs respectively. In 100 cases of vaginal trichomoniasis treated with panidazole at the dose of 1.0 g per day for seven days in half of the patients and for 10 days in the other half, we obtained 50% and 60% cure rates. The results of our studies with both amoebiasis and trichomoniasis were not superior to those obtained with metronidazole and other nitroimidazole derivatives. Side effects were found in 74% of the patients treated for amoebiasis and in 46% of the cases treated for trichomoniasis. No toxic effects were revealed by haematological, biochemical and renal function tests nor by cardiovascular studies.

Voogd CE, et al. The mutagenic action of nitroimidazoles. II. Tinidazole, ipronidazole, panidazole and ornidazole. Mutat Res. 1977 Apr;48(2):155-61.
Abstract:The 5-nitroimidazoles tinidazole (Fasigyn), ipronidazole (Ro-7-1554), panidazole and ornidazole (Tiberal, Ro-7-0207) in concentrations of 0.02--1 mM per liter increased the mutation frequency of Klebsiella pneumoniae. Escherichia coli K12 and Citrobacter freundii to streptomycin resistance, including streptomycin dependence, in Luria and Delbrück's fluctuation test. At low concentration (0.1 mM), the increase of the mutation frequency caused by each compound was nearly the same, i.e. 3--4 times the spontaneous mutation frequency. At higher concentrations, considerable differences between the mutagenic activities of the compounds occurred.

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