購物車 
-
PLpro inhibitor
- names：
PLpro inhibitor
- CAS號：
1093070-14-4
MDL Number： No data available - MF(分子式)： C22H22N2O2 MW(分子量)： 346.42
- EINECS:No data available Reaxys Number:No data available
- Pubchem ID:312811351 Brand:BIOFOUNT
PLpro inhibitor(1093070-14-4)是一種有效的木瓜蛋白酶樣蛋白酶（PLpro）抑制劑，PLpro抑制劑具有顯著的抗病毒活性。
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM000881-5mg | 5mg | 99.7% | ￥ 3295.00 | ￥ 3295.00 | 2-3天 | ￥ 0.00 | ||
| YZM000881-2mg | 2mg | 99.7% | ￥ 2116.00 | ￥ 2116.00 | 2-3天 | ￥ 0.00 |
| 中文別名 | PLpro inhibitor(1093070-14-4),5-(乙酰氨基)-2-甲基-N-[(1R)-1-(1-萘基)乙基]苯甲酰胺,PLpro抑制劑 |
| 英文別名 | PLpro inhibitor,1093070-14-4 |
| CAS號 | 1093070-14-4 |
| Inchi | InChI=1S/C22H22N2O2/c1-14-11-12-18(24-16(3)25)13-21(14)22(26)23-15(2)19-10-6-8-17-7-4-5-9-20(17)19/h4-13,15H,1-3H3,(H,23,26)(H,24,25)/t15-/m1/s1 |
| InchiKey | KGPYBLOBHQLIET-OAHLLOKOSA-N |
| 分子式 Formula | C22H22N2O2 |
| 分子量 Molecular Weight | 346.42 |
| 溶解度Solubility | 生物體外In Vitro:DMSO溶解度≥ 42 mg/mL(121.24 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知. |
| 性狀 | 白色至灰白色固體粉末 |
| 儲藏條件 Storage conditions | 在-20°C條件下保存3年,在4°C條件下保存2年 |
PLpro inhibitor(1093070-14-4)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染
PLpro inhibitor(1093070-14-4) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:PLpro inhibitor(1093070-14-4),PLpro inhibitor的作用,PLpro抑制劑,PLpro inhibitor的效果,PLpro inhibitor的使用,PLpro inhibitor的合成,PLpro inhibitor的生產,PLpro inhibitor的外觀,PLpro inhibitor的溶解度,PLpro inhibitor的MSDS
| 產品說明 | PLpro inhibitor(1093070-14-4)是一種有效的木瓜蛋白酶樣蛋白酶（PLpro）抑制劑，PLpro抑制劑具有顯著的抗病毒活性。 |
| Introduction | PLpro inhibitor (1093070-14-4) is a potent papain-like protease (PLpro) inhibitor, PLpro inhibitor has significant antiviral activity. |
| Application1 | |
| Application2 | |
| Application3 |
PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1 μM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells.
| 警示圖 | |
| 危險性 | warning |
| 危險性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害 |
| 安全防護 | P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理 |
| 備注 | 實驗過程中防止吸入、食入，做好安全防護 |
Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.
Lee H1, Lei H1, Santarsiero BD1, Gatuz JL1, Cao S1, Rice AJ1, Patel K1, Szypulinski MZ1, Ojeda I, Ghosh AK2, Johnson ME1. ACS Chem Biol. 2015 Jun 19;10(6):1456-65. doi: 10.1021/cb500917m. Epub 2015 Mar 16.
The Middle East Respiratory Syndrome coronavirus (MERS-CoV) papain-like protease (PLpro) blocking loop 2 (BL2) structure differs significantly from that of SARS-CoV PLpro, where it has been proven to play a crucial role in SARS-CoV PLpro inhibitor binding. Four SARS-CoV PLpro lead inhibitors were tested against MERS-CoV PLpro, none of which were effective against MERS-CoV PLpro. Structure and sequence alignments revealed that two residues, Y269 and Q270, responsible for inhibitor binding to SARS-CoV PLpro, were replaced by T274 and A275 in MERS-CoV PLpro, making critical binding interactions difficult to form for similar types of inhibitors. High-throughput screening (HTS) of 25?000 compounds against both PLpro enzymes identified a small fragment-like noncovalent dual inhibitor. Mode of inhibition studies by enzyme kinetics and competition surface plasmon resonance (SPR) analyses suggested that this compound acts as a competitive inhibitor with an IC50 of 6 μM against MERS-CoV PLpro, indicating that it binds to the active site, whereas it acts as an allosteric inhibitor against SARS-CoV PLpro with an IC50 of 11 μM.
Lee H1, Lei H1, Santarsiero BD1, Gatuz JL1, Cao S1, Rice AJ1, Patel K1, Szypulinski MZ1, Ojeda I, Ghosh AK2, Johnson ME1. ACS Chem Biol. 2015 Jun 19;10(6):1456-65. doi: 10.1021/cb500917m. Epub 2015 Mar 16.
The Middle East Respiratory Syndrome coronavirus (MERS-CoV) papain-like protease (PLpro) blocking loop 2 (BL2) structure differs significantly from that of SARS-CoV PLpro, where it has been proven to play a crucial role in SARS-CoV PLpro inhibitor binding. Four SARS-CoV PLpro lead inhibitors were tested against MERS-CoV PLpro, none of which were effective against MERS-CoV PLpro. Structure and sequence alignments revealed that two residues, Y269 and Q270, responsible for inhibitor binding to SARS-CoV PLpro, were replaced by T274 and A275 in MERS-CoV PLpro, making critical binding interactions difficult to form for similar types of inhibitors. High-throughput screening (HTS) of 25?000 compounds against both PLpro enzymes identified a small fragment-like noncovalent dual inhibitor. Mode of inhibition studies by enzyme kinetics and competition surface plasmon resonance (SPR) analyses suggested that this compound acts as a competitive inhibitor with an IC50 of 6 μM against MERS-CoV PLpro, indicating that it binds to the active site, whereas it acts as an allosteric inhibitor against SARS-CoV PLpro with an IC50 of 11 μM.
對不起，暫無產品評價！
MSDS
SDS 1.0 中文
展開
SDS 1.0 英文
展開
- 相關產品
-
< >
- 推薦產品
-
< >
- 最新產品
-
< >
新聞
怎么做細胞爬片免疫組化染色實驗
細胞爬片免疫組化染色，是通過細胞爬片是讓玻片浸在細胞培養基內，細胞在玻片上生長，主要用于組織學，免疫組織化學...
2020/7/20 22:04:33
提取病毒RNA的實驗方法
提取病毒RNA方法分別有：異硫氰酸胍的提取病毒RNA方法、TRIzol LS提取法、Trizol法提取法等等...
2020/7/22 20:29:26
細胞培養耗材技術領先性
細胞培養板行業面臨的核心痛點是：常規TC處理后表面親水角隨時間衰減，影響長期培養穩定性，BIOFOUNT高分...
2026/4/28 15:12:51
細胞培養耗材關鍵性能
細胞培養板的水接觸角作為表面潤濕性的核心指標，直接影響細胞貼壁、增殖、分化及功能表達，其中40°（低接觸角/...
2026/4/28 14:52:44
chelex 100樹脂國產替代之路-BIOFOUNT范德生物
Chelex 100螯合離子交換樹脂對銅、鐵和其他重金屬?的偏好顯著高于對鈉、鉀等一價陽離子的偏好。它對二價...
2025/11/4 14:22:46
9月開學季——助研新學期 范德送好禮
2025/8/28 15:30:55
Waxfilm 實驗室封口膜：技術與國際市場的雙重突破
在實驗室耗材領域，封口膜是保障實驗準確性與穩定性的關鍵產品之一。近年來，Waxfilm?實驗室封口膜憑借其卓...
2025/5/13 13:03:40
Waxfilm實驗室封口膜的5大突破
Waxfilm實驗室封口膜作為生物功能膜領域的國產技術突破和品牌突破，是生物領域中國技術發展的縮影。
2025/5/6 17:02:07
各種微流控芯片鍵合方法的優缺點
微流控芯片鍵合：目前主要有激光焊接、熱壓鍵合、膠鍵合、超音波焊接，每種方法都有各自的優缺點。本文主要介紹聚酯...
2023/7/28 10:43:09
新一代微流控鍵合解決方案
微流控鍵合解決方案：微流控芯片制造的一個重要環節，也是最容易被忽視的--芯片鍵合。其中一個重要因素是：微流控...
2023/7/27 12:44:28
