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PF429242 dihydrochloride

NMR下載 COA and HPLC MSDS下載
names：
PF429242 dihydrochloride
CAS號：
2248666-66-0
MDL Number： No data available
MF(分子式)： C25H37Cl2N3O2 MW(分子量)： 482.49
EINECS:No data available Reaxys Number:No data available
Pubchem ID:90488837 Brand:BIOFOUNT

PF429242 dihydrochloride(2248666-66-0)是固醇調節元件結合蛋白（SREBP）位點1蛋白酶（IC50 = 0.175μM）的可逆競爭性抑制劑，是膽固醇，脂肪酸和葡萄糖代謝的轉錄調節劑。PF429242 dihydrochloride減少了小鼠肝臟中膽固醇和脂肪酸的合成。

貨品編碼	規格	純度	價格 (￥)	現價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000886-10mg	10mg	98.7%	￥ 1568.00	￥ 1568.00		2-3天	- +	￥ 0.00
YZM000886-5mg	5mg	98.7%	￥ 858.00	￥ 858.00		2-3天	- +	￥ 0.00

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中文別名	PF429242 dihydrochloride(2248666-66-0),PF429242 (dihydrochloride),PF 429242 dihydrochloride
英文別名	PF429242 dihydrochloride,2248666-66-0,PF429242 (dihydrochloride),PF 429242 dihydrochloride
CAS號	2248666-66-0
Inchi	InChI=1S/C25H35N3O2.2ClH/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3;;/h6-13,23,26H,4-5,14-19H2,1-3H3;2*1H/t23-;;/m1../s1
InchiKey	GSUZWFZKTIOWTI-MQWQBNKOSA-N
分子式 Formula	C25H37Cl2N3O2
分子量 Molecular Weight	482.49
溶解度Solubility	生物體外In Vitro:DMSO溶解度≥ 83.3 mg/mL(172.65 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性狀	白色至灰白色固體粉末
儲藏條件 Storage conditions	在-20°C條件下保存3年,在4°C條件下保存2年

PF429242 dihydrochloride(2248666-66-0)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業生物廢氣物處理公司處理，以免造成環境污染

PF429242 dihydrochloride(2248666-66-0) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	PF429242 dihydrochloride(2248666-66-0)是固醇調節元件結合蛋白（SREBP）位點1蛋白酶的可逆競爭性抑制劑
Introduction	PF429242 dihydrochloride (2248666-66-0) is a reversible competitive inhibitor of sterol regulatory element binding protein (SREBP) site 1 protease
Application1
Application2
Application3

10 μM PF-429242 inhibits endogenous SREBP processing in Chinese hamster ovary cells. PF-429242 also down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC₅₀ of 0.5 μM. The addition of PF-429242 (30 μM) shows statistically significant suppression of infectious viral titers and viral RNA copies in the cell culture fluids. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells. PF-429242 efficiently prevents the processing of GPC from the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV, which correlates with the compound's potent antiviral activity against LCMV and LASV in cultured cells.

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續沖洗+P337如果眼睛刺激持續+P2393獲得醫療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護