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ESI-09

NMR下載 COA and HPLC MSDS下載
names：
ESI-09
CAS號：
263707-16-0
MDL Number： MFCD00109218
MF(分子式)： C16H15ClN4O2 MW(分子量)： 330.77
EINECS:No data available Reaxys Number:No data available
Pubchem ID:6077765 Brand:BIOFOUNT

ESI-09(263707-16-0)是一種新型非環(huán)狀核苷酸EPAC拮抗劑，能夠特異性阻斷細(xì)胞內(nèi)EPAC介導(dǎo)的Rap1活化和Akt磷酸化，以及EPAC介導(dǎo)的胰腺β細(xì)胞中胰島分泌。另一方面，ESI-09不抑制AsPC1細(xì)胞中表皮生長因子(EGF)誘導(dǎo)的Akt磷酸化。在胰腺癌細(xì)胞中，ESI-09通過劑量依賴性降低007-AM誘導(dǎo)的細(xì)胞粘附而抑制細(xì)胞遷移和侵襲。ESI-09顯著降低人臍靜脈內(nèi)皮細(xì)胞中總細(xì)菌數(shù)。ESI-09有效拮抗CPT-cAMP誘導(dǎo)的Schwann細(xì)胞(SC)分化以及髓鞘的形成。在SC神經(jīng)元培養(yǎng)基中，ESI-09顯著降低O1陽性和MBP陽性的數(shù)量，而不影響神經(jīng)元或SCs自身的健康。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000889-10mg	10mg	98%	￥ 1230.00	￥ 1230.00		2-3天	- +	￥ 0.00
YZM000889-5mg	5mg	98%	￥ 698.00	￥ 698.00		2-3天	- +	￥ 0.00

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中文別名	ESI-09(263707-16-0),ESI09,ESI 09
英文別名	ESI-09,263707-16-0,ESI09,ESI 09
CAS號	263707-16-0
Inchi	InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
InchiKey	DXEATJQGQHDURZ-DEDYPNTBSA-N
分子式 Formula	C16H15ClN4O2
分子量 Molecular Weight	330.77
溶解度Solubility	生物體外In Vitro:DMSO溶解度≥ 47 mg/mL(142.09 mM)H2O< 0.1 mg/mL(insoluble)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性狀	灰白色至橙色固體粉末
儲藏條件 Storage conditions	在-20°C條件下保存3年,在4°C條件下保存2年

ESI-09(263707-16-0)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

ESI-09(263707-16-0)Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:ESI-09(263707-16-0),ESI-09抑制劑,ESI-09試劑,ESI-09的作用,ESI-09的純度,ESI-09雜質(zhì),ESI-09的外觀,ESI-09的溶解度,ESI-09的用途,ESI-09的合成,ESI-09的生產(chǎn),ESI-09的注意事項(xiàng),ESI-09的MSDS

產(chǎn)品說明	ESI-09(263707-16-0)是一種新型非環(huán)狀核苷酸EPAC拮抗劑，能夠特異性阻斷細(xì)胞內(nèi)EPAC介導(dǎo)的Rap1活化和Akt磷酸化
Introduction	ESI-09 (263707-16-0) is a new type of non-cyclic nucleotide EPAC antagonist, which can specifically block EPAC-mediated Rap1 activation and Akt phosphorylation in cells
Application1
Application2
Application3

ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.ESI-09 is a novel noncyclic nucleotide EPAC antagonist that is capable of specifically blocking intracellular EPAC-mediated Rap1 activation and Akt phosphorylation, as well as EPAC-mediated insulin secretion in pancreatic β cells. EPAC1 plays an important role in pancreatic cancer cell migration and invasion, and thus represents a potential target for developing novel therapeutic strategies for pancreatic cancer.

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue

Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC)

Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

[Differences in the responses of taste receptors to organic and inorganic acids with changes in the concentration of bicarbonate in the solution]

Epac-inhibitors: facts and artefacts.
Rehmann H1. Sci Rep. 2013 Oct 23;3:3032. doi: 10.1038/srep03032.
cAMP is a universal second messenger. Its signalling is mediated by protein kinase A, Epac and certain types of ion channels in mammalians. cAMP signalling is involved in many physiological processes ranging from vision to the control of insulin secretion, pacemaker activity and gene transcription and therefore selective pharmacological interference is of medical interest. Whereas selective inhibitors of PKA and selective activators of Epac are well established, no inhibitors of Epac were available until recently. Here the action of four of the novel Epac inhibitors was analysed by biophysical means. ESI-05 is confirmed as a selective inhibitor of Epac2. No direct action of Brefeldin A on Epac could be demonstrated. ESI-09 and HJC0197 were found to act as chemicals with general protein denaturing properties and do not act on Epac selectively.

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MSDS

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