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Daun02
- names：
Daun02
- CAS號：
290304-24-4
MDL Number： MFCD22124459 - MF(分子式)： C41H44N2O20 MW(分子量)： 884.79
- EINECS:No data available Reaxys Number:No data available
- Pubchem ID:74891316 Brand:BIOFOUNT
Daun02(290304-24-4)使神經(jīng)元整體失活會導(dǎo)致長期飲酒減少。此外，在CeA中注射Daun02的依賴動物體內(nèi)的體細(xì)胞癥狀顯著減少。
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM000903-5mg | 5mg | 98% | ￥ 2835.00 | ￥ 2835.00 | 2-3天 | ￥ 0.00 | ||
| YZM000903-2mg | 2mg | 98% | ￥ 1755.00 | ￥ 1755.00 | 2-3天 | ￥ 0.00 |
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| 中文別名 | Daun02(290304-24-4),Daun 02,Daun-02 |
| 英文別名 | Daun02,290304-24-4 |
| CAS號 | 290304-24-4 |
| Inchi | InChI=1S/C41H44N2O20/c1-15-31(46)20(42-40(54)59-14-17-7-8-22(21(9-17)43(56)57)62-39-38(53)37(52)34(49)25(13-44)63-39)10-26(60-15)61-24-12-41(55,16(2)45)11-19-28(24)36(51)30-29(33(19)48)32(47)18-5-4-6-23(58-3)27(18)35(30)50/h4-9,15,20,24-26,31,34,37-39,44,46,48-49,51-53,55H,10-14H2,1-3H3,(H,42,54)/t15-,20-,24-,25+,26-,31+,34-,37-,38+,39+,41-/m0/s1 |
| InchiKey | BOIXMGNMIWJAEW-LCTCPDETSA-N |
| 分子式 Formula | C41H44N2O20 |
| 分子量 Molecular Weight | 884.79 |
| 溶解度Solubility | 生物體外In Vitro:DMSO溶解度≥ 100 mg/mL(113.02 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知. |
| 性狀 | 棕色到酒紅色固體粉末 |
| 儲藏條件 Storage conditions | -20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月 |
Daun02(290304-24-4)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染
Daun02(290304-24-4) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:Daun02(290304-24-4),Daun02試劑,Daun02抑制劑,Daun02的純度,Daun02的作用,Daun02的外觀,Daun02的溶解度,Daun02的效果,Daun02的合成,Daun02的應(yīng)用,Daun02的結(jié)構(gòu)式,Daun02的生產(chǎn),Daun02的注意事項(xiàng)
| 產(chǎn)品說明 | Daun02(290304-24-4)使神經(jīng)元整體失活會導(dǎo)致長期飲酒減少,在CeA中注射Daun02的依賴動物體內(nèi)的體細(xì)胞癥狀顯著減少。 |
| Introduction | Daun02 (290304-24-4) inactivation of neurons as a whole can lead to a reduction in long-term alcohol consumption, and the somatic withdrawal symptoms in dependent animals injected with Daun02 in CeA a |
| Application1 | Daun02是拓?fù)洚悩?gòu)酶抑制劑Daunorubicin的前藥 |
| Application2 | |
| Application3 |
Abstinence from alcohol is associated with the recruitment of neurons in the central nucleus of the amygdala (CeA) in nondependent rats that binge drink alcohol and in alcohol-dependent rats. However, whether the recruitment of this neuronal ensemble in the CeA is causally related to excessive alcohol drinking or if it represents a consequence of excessive drinking remains unknown. We tested the hypothesis that the recruitment of a neuronal ensemble in the CeA during abstinence is required for excessive alcohol drinking in nondependent rats that binge drink alcohol and in alcohol-dependent rats. We found that inactivation of the CeA neuronal ensemble during abstinence significantly decreased alcohol drinking in both groups. In nondependent rats, the decrease in alcohol intake was transient and returned to normal the day after the injection. In dependent rats, inactivation of the neuronal ensemble with Daun02 produced a long-term decrease in alcohol drinking. Moreover, we observed a significant reduction of somatic withdrawal signs in dependent animals that were injected with Daun02 in the CeA. These results indicate that the recruitment of a neuronal ensemble in the CeA during abstinence from alcohol is causally related to excessive alcohol drinking in alcohol-dependent rats, whereas a similar neuronal ensemble only partially contributed to alcohol-binge-like drinking in nondependent rats.
| 警示圖 | |
| 危險(xiǎn)性 | warning |
| 危險(xiǎn)性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害 |
| 安全防護(hù) | P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理 |
| 備注 | 實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù) |
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