購物車 
-
MC-Val-Cit-PAB-Auristatin E
- names：
MC-Val-Cit-PAB-Auristatin E
- CAS號：
2055896-77-8
MDL Number： - MF(分子式)： C68H108N11O13 MW(分子量)： 1287.65
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
MC-Val-Cit-PAB-Auristatin E(2055896-77-8) 是抗體-藥物偶聯(lián)物的一部分，由細胞毒性微管蛋白修飾劑 Auristatin E 和 ADC linker MC-Val-Cit-PAB 連接而成
| 貨品編碼 | 規(guī)格 | 純度 | 價格 (￥) | 現(xiàn)價(￥) | 特價(￥) | 庫存描述 | 數(shù)量 | 總計 (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM001099-250mg | 250mg | >95% | ￥ 0.00 | ￥ 0.00 | Backorder | ￥ 0.00 | ||
| YZM001099-100mg | 100mg | >95% | ￥ 0.00 | ￥ 0.00 | Backorder | ￥ 0.00 |
| 中文別名 | MC-Val-Cit-PAB-Auristatin E(2055896-77-8);MC Val Cit PAB Auristatin E |
| 英文別名 | MC-Val-Cit-PAB-Auristatin E,2055896-77-8 |
| CAS號 | 2055896-77-8 |
| Inchi | No data available |
| InchiKey | No data available |
| 分子式 Formula | C68H108N11O13 |
| 分子量 Molecular Weight | 1287.65 |
| 溶解度Solubility | |
| 性狀 | Solid |
| 儲藏條件 Storage conditions | 短期1-2周儲存在-4℃條件下就行，長期儲存（1-2年）需在-20℃條件下存儲 |
MC-Val-Cit-PAB-Auristatin E(2055896-77-8)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染
MC-Val-Cit-PAB-Auristatin E(2055896-77-8) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:MC-Val-Cit-PAB-Auristatin E(2055896-77-8),MC-Val-Cit-PAB-Auristatin E試劑,MC-Val-Cit-PAB-Auristatin E的作用,MC-Val-Cit-PAB-Auristatin E的外觀,MC-Val-Cit-PAB-Auristatin E的溶解度,MC-Val-Cit-PAB-Auristatin E的廠家,MC-Val-Cit-PAB-Auristatin E的價格,MC-Val-Cit-PAB-Auristatin E的MSDS
| 產(chǎn)品說明 | MC-Val-Cit-PAB-Auristatin E(2055896-77-8)是ADC的藥物連接物偶聯(lián)物，具有有效的抗腫瘤活性。 |
| Introduction | MC-Val-Cit-PAB-Auristatin E (2055896-77-8) is a drug linker conjugate of ADC with effective anti-tumor activity. |
| Application1 | MC-Val-Cit-PAB-Auristatin E is a drug-linker conjugate for ADC with potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker MC-Val-Cit-PAB. |
| Application2 | |
| Application3 |
| 警示圖 | |
| 危險性 | warning |
| 危險性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害 |
| 安全防護 | P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理 |
| 備注 | 實驗過程中防止吸入、食入，做好安全防護 |
| Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119. |
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates
Staben LR, et al.
The reversible attachment of a small-molecule drug to a carrier for targeted delivery can improve pharmacokinetics and the therapeutic index. Previous studies have reported the delivery of molecules that contain primary and secondary amines via an amide or carbamate bond; however, the ability to employ tertiary-amine-containing bioactive molecules has been elusive. Here we describe a bioreversible linkage based on a quaternary ammonium that can be used to connect a broad array of tertiary and heteroaryl amines to a carrier protein. Using a concise, protecting-group-free synthesis we demonstrate the chemoselective modification of 12 complex molecules that contain a range of reactive functional groups. We also show the utility of this connection with both protease-cleavable and reductively cleavable antibody-drug conjugates that were effective and stable in vitro and in vivo. Studies with a tertiary-amine-containing antibiotic show that the resulting antibody-antibiotic conjugate provided appropriate stability and release characteristics and led to an unexpected improvement in activity over the conjugates previously connected via a carbamate.
Staben LR, et al.
The reversible attachment of a small-molecule drug to a carrier for targeted delivery can improve pharmacokinetics and the therapeutic index. Previous studies have reported the delivery of molecules that contain primary and secondary amines via an amide or carbamate bond; however, the ability to employ tertiary-amine-containing bioactive molecules has been elusive. Here we describe a bioreversible linkage based on a quaternary ammonium that can be used to connect a broad array of tertiary and heteroaryl amines to a carrier protein. Using a concise, protecting-group-free synthesis we demonstrate the chemoselective modification of 12 complex molecules that contain a range of reactive functional groups. We also show the utility of this connection with both protease-cleavable and reductively cleavable antibody-drug conjugates that were effective and stable in vitro and in vivo. Studies with a tertiary-amine-containing antibiotic show that the resulting antibody-antibiotic conjugate provided appropriate stability and release characteristics and led to an unexpected improvement in activity over the conjugates previously connected via a carbamate.
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